Microglia activation is essential for BMP7-mediated retinal reactive gliosis
Date
2017
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American English
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BioMed Central
Abstract
Our previous studies have shown that BMP7 is able to trigger activation of retinal macroglia. However, these studies showed the responsiveness of Müller glial cells and retinal astrocytes in vitro was attenuated in comparison to those in vivo, indicating other retinal cell types may be mediating the response of the macroglial cells to BMP7. In this study, we test the hypothesis that BMP7-mediated gliosis is the result of inflammatory signaling from retinal microglia.
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Dharmarajan, S., Fisk, D. L., Sorenson, C. M., Sheibani, N., & Belecky-Adams, T. L. (2017). Microglia activation is essential for BMP7-mediated retinal reactive gliosis. Journal of Neuroinflammation, 14, 76. https://doi.org/10.1186/s12974-017-0855-0
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1742-2094
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Journal of Neuroinflammation
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Article
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Final published version