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179 Indiana Medical Student Program for Research and Scholarship (IMPRS): A 6-year analysis of program outcomes (2018-2023)
(Cambridge University Press, 2026-05-08) Nguyen, Anne; Nagesh, Nihal; Hornak, Alena Frances; Eldredge Hunter, Martha; Sinha, Arunabh; Jackson, Luke Randall; Ramirez, Mirian; Li, Allison; Ruth Lilly Medical Library, School of Medicine
Objectives/Goals: To assess participation, satisfaction, and scholarly outcomes of IMPRS, a structured 10-week summer research program for rising second-year medical students at Indiana University School of Medicine (IUSM), one of the largest medical schools in the nation, across six cohorts (2018-2023). Methods/Study Population: We conducted a retrospective analysis of 1,090 IMPRS participants across six cohorts (2018–2023) at IUSM’s nine regional campuses. Students engaged in clinical, translational, community-based, and health outcomes research, culminating in an annual poster symposium. Program data included application numbers, participation rates, and satisfaction surveys. Scholarly outcomes were assessed via systematic PubMed and Scopus searches for publications derived from student projects. Search strategies combined student and mentor names, with results matched against symposium abstracts based on shared title keywords, content, topics, findings, or methodology. These matches were then used to calculate publication rates, time to publication, and analyze trends across cohorts. Results/Anticipated Results: Application rates increased from 23% (2017) to 76% (2023), with 21% to 61% ultimately participating. From 2017 to 2023, applications rose 77% (155 to 274), and participants increased 114% (103 to 220). Over six years, 1,090 students across IUSM’s nine campuses took part in IMPRS, resulting in 313 unique publications. The overall publication rate was 30.83%, with a mean time to publication of 22.6 months (IQR 13.0–30.8). Participant satisfaction remained high, with over 90% of students agreeing the program was a positive and productive experience. Discussion/Significance of Impact: IMPRS demonstrates a strong model for structured summer research, with a 30.83% publication rate comparable to similar programs (24-34%). High satisfaction and sustained growth indicate IMPRS successfully fosters scholarly development and cultivates future physician-scientists.
200 From Community College to translational science: Building a bridge through immersion research experiences
(Cambridge University Press, 2026-05-08) King, Jalysa; Allen, Matthew; Anatomy, Cell Biology and Physiology, School of Medicine
Objectives/Goals: To describe how the Ivy Tech Community College and Indiana CTSI partnership creates early entry points into translational science, expands access for community college students, and strengthens the biomedical research workforce. Methods/Study Population: The Indiana CTSI partnered with Ivy Tech, a community college system that has campuses throughout the state, to launch a Research Scholars Program. This is a 10-week summer immersion experience introducing community college students to biomedical and health sciences. Students are matched with research teams at Indiana University, Purdue University, or Notre Dame (depending on where the student lives), engaging in 35 hours per week in research activities and professional development. Students receive a stipend and may be provided a laptop if needed. Recruitment is supported through collaboration with Ivy Tech faculty and staff, including classroom outreach, referrals, and information sessions. Results/Anticipated Results: Across two cohorts, the program achieved 17 completions by community college students from multiple Ivy Tech campuses, including one who returned for a second summer. Students gained hands-on research skills, professional development, and communication training, presenting their findings at program-end symposia and a virtual presentation connecting participants across campuses. Outcomes include poster presentations at regional meetings, transfers to four-year institutions, and pursuit of health and biomedical careers. Several students have continued working with mentors, and one was hired part-time by their lab, underscoring the program’s statewide impact through partnerships with IU, Purdue, and Notre Dame. Discussion/Significance of Impact: This program highlights how the Indiana CTSI–Ivy Tech partnership expands access to translational science for learners within community college settings. Statewide collaboration, sustained mentoring, and student outcomes together provide a scalable model for workforce development.
Clinical Characteristics and Outcomes in Intra-aortic Balloon Pump-Supported Cardiogenic Shock Among Patients Transferred to Tertiary Care Centers
(Elsevier, 2026-04-07) Sundermeyer, Jonas; Kataria, Rachna; Garan, A. Reshad; Li, Song; Ton, Van-Khue; Zweck, Elric; Kanwar, Manreet K.; Hernandez-Montfort, Jaime; Sinha, Shashank S.; Abraham, Jacob; John, Kevin J.; Sangal, Paavni; Mahr, Claudius; Burkhoff, Daniel; Kapur, Navin K.; Cardiogenic Shock Working Group Academic Research Consortium; Medicine, School of Medicine
Background: The intra-aortic balloon pump (IABP) is a commonly used temporary mechanical circulatory support device in cardiogenic shock (CS). A substantial proportion of patients receive IABP at referring hospitals prior to transfer. The aim of this study was to compare clinical characteristics, treatment strategies, and outcomes between transferred and nontransferred IABP-treated patients with all-cause CS, acute myocardial infarction-related CS (AMI-CS), and heart failure-related CS (HF-CS).
Methods: Intra-aortic balloon pump-treated CS patients from the multicenter Cardiogenic Shock Working Group registry (2020-2024) were analyzed. Adjusted logistic regression models were used to assess associations between transfer status and in-hospital mortality, native heart survival, heart replacement therapies, and in-hospital complications.
Results: Among 2112 IABP-treated patients (36.6% AMI-CS, 48.9% HF-CS), 652 (30.9%) were primarily treated at referring centers and transferred. Transferred patients more frequently had AMI-CS (57.8% vs 27.1%) and less often HF-CS (27.5% vs 58.4%) than nontransferred subjects. Transfer was associated with higher in-hospital mortality (33.1% vs 26.4%; adjusted odds ratio [aOR], 1.38; 95% CI, 1.13-1.68; P < .001), with the strongest association observed in non-AMI-CS/non-HF-CS (40.6% vs 28.3%; aOR, 1.73; 95% CI, 1.07-3.04; P = .026). Complications were linked to transfer status, including stroke (aOR, 1.83; 95% CI, 1.30-2.57; P < .001), limb ischemia (aOR, 2.17; 95% CI, 1.53-3.09; P < .001), and in-hospital cardiac arrest (aOR, 1.37; 95% CI, 1.08-1.72; P = .006).
Conclusions: Transfer status was independently associated with higher in-hospital mortality and complications. These findings emphasize the importance of structured referral pathways and heightened awareness at hub centers for this potentially high-risk IABP-treated CS cohort.
Animal Models of Malaria-Associated Acute Kidney Injury
(Elsevier, 2025) Collins, Mamudu; Polidoro, Rafael; Gallego-Delgado, Julio; Pediatrics, School of Medicine
Malaria-associated acute kidney injury (MAKI) is a critical complication of severe malaria, particularly in infections caused by Plasmodium falciparum, which is responsible for most malaria-related deaths. MAKI affects 40-60% ofs severe malaria cases, significantly increasing mortality, especially in pediatric patients. Its pathogenesis remains unclear, though mechanisms such as hemodynamic disturbances, oxidative stress, and immune responses are implicated. Animal models, particularly murine and nonhuman primates, provide valuable insights into MAKI's underlying processes. Murine models, though not fully replicative of human malaria, allow for the exploration of immune responses, kidney injury biomarkers, and therapeutic approaches. Nonhuman primate models, closer to human physiology, offer additional complexity for studying malaria's renal manifestations. This review critically examines the existing animal models, addressing their strengths and limitations in replicating human MAKI and highlighting the importance of advancing research in this field to develop targeted treatments.
IDOL Deficiency Inhibits Cholesterol-Rich Diet-Induced Atherosclerosis in Rabbits
(American Heart Association, 2025) Koike, Tomonari; Koike, Yui; Niimi, Manabu; Guo, Yanhong; Yang, Dongshan; Song, Jun; Xu, Jie; Tang, Xiangming; Ren, Zhuoying; Kong, Xiangbo; Liu, Hongyu; Zhao, Xiangjie; Zhu, Tianqing; Li, Ruiting; Wen, Bo; Sun, Duxin; Rom, Oren; Han, Renzhi; Fan, Jianglin; Garcia-Barrio, Minerva T.; Zhang, Jifeng; Chen, Y. Eugene; Pediatrics, School of Medicine