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Strain-based biomarkers at the skin surface differentiate asymmetries in soft tissue mobility associated with myofascial pain
(Elsevier, 2025-12) Kao, Anika R.; Loghmani, Terry M.; Gerling, Gregory J.; Physical Therapy, School of Health and Human Sciences
Soft tissue manipulation is used widely to assess myofascial tissue qualitatively but lacks objective measures. To quantify the mobility of myofascial tissue, this effort derives optical biomarkers from the skin surface, as observed in the hands-on workflow of clinicians. Digital image correlation using three high-resolution cameras captures the cervicothoracic region as a clinician deeply engages and stretches the skin and myofascial tissue. Nineteen participants were positioned prone and marked with semi-permanent tattoos, optimized for tracking tissue without compromising its natural mechanics. Tissue mobility was then clinically assessed both bilaterally (left and right sides of body) and directionally (superior and inferior directions of pull). Eleven strain-based biomarkers were derived per tissue pull. With participants' data aggregated, the sides of the body were indistinct, though pull in the superior direction was distinct from that in the inferior direction. Given substantial variance in the biomarkers' absolute values between participants, we then evaluated each person individually. Therein, distinct tissue behaviors were observed. In particular, bilateral differences were identified in nine participants, eight of whom reported discrepancies in pain between their left and right sides, while directional distinctions were observed in sixteen participants, as expected given similar anatomical tissue structures between individuals. In our sample of participants, optical skin surface tracking and derived strain-based biomarkers identified asymmetrical distinctions in bilateral mobility, which correspond with self-reported pain. Such objective assessment of myofascial tissue stiffness is important in monitoring and treating chronic musculoskeletal pain, which afflicts half of the U.S. adult population.
On an identity by Ercolani, Lega, and Tippings
(arXiv, 2024) Yattselev, Maxim L.; Mathematical Sciences, School of Science
The 3D-printed shell complete denture technique: Simplifying prosthodontic diagnosis prior to implant planning
(Wiley, 2026-02) Azpiazu-Flores, Francisco X.; Yang, Chao-Chieh; Lin, Wei-Shao; Polido, Waldemar D.; Morton, Dean; Prosthodontics, School of Dentistry
Traditionally, artificial teeth arrangements or the definitive complete dentures are used to establish important prosthodontic parameters such as the occlusal plane orientation, vertical dimension, and the incisal edge position. The relationship of these elements with the underlying bony structures is commonly evaluated using advanced planning protocols such as the dual scan technique. This technique article presents an uncomplicated alternative approach to establish these parameters intraorally using a 3D-printed shell complete denture generated from a 3D scan of the patient's existing complete denture.
Perspective: The complex relationship between charge, mobility, and gas-phase protein structure
(Wiley, 2024-05) Webb, Ian K.; Chemistry and Chemical Biology, School of Science
Ion mobility spectrometry coupled to mass spectrometry (IMS/MS) is a widely used tool for biomolecular separations and structural elucidation. The application of IMS/MS has resulted in exciting developments in structural proteomics and genomics. This perspective gives a brief background of the field, addresses some of the important issues in making structural measurements, and introduces complementary techniques.
The relationship between voluntary and involuntary muscle contractile properties in young women
(Cold Spring Harbor Laboratory, 2024) Fry, Madison J.; Zoughaib, William S.; Hoffman, Richard L.; Coggan, Andrew R.; Health Sciences, School of Health and Human Sciences
Isokinetic dynamometry and neuromuscular electrical stimulation (NMES) are two commonly used approaches for quantifying muscle contractile properties. Few studies, however, have investigated the relationship between such testing procedures, particularly in women.
PURPOSE To determine the relationship between voluntary isometric and isokinetic torque and torque during involuntary, electrically evoked contractions of the knee extensor muscles.
METHODS Thirty young women (age 23 ± 5 y) performed maximal knee extensions on an isokinetic dynamometer at angular velocities of 0, 1.57, 3.14, 4.71, and 6.28 rad/s. Following this testing, NMES of the quadriceps (400 V, 200 µs) was used to determine unpotentiated and potentiated twitch contractile properties. The quadriceps were also stimulated with 1 s trains at 1, 5, 10, 15, 20, 25, 30, 35, 40, 60, 80, and 100 Hz to determine the torque-frequency relationship.
RESULTS Voluntary torques at 1.57 and 3.14 rad/s were significantly correlated (i.e., multiplicity-adjusted P≤0.01) with the rate of torque development during potentiated twitches (r = 0.60 and 0.55, respectively). No other significant correlations were found between voluntary and involuntary muscle contractile properties, including various measures of the torque-frequency relationship.
CONCLUSION Although there is some relationship between voluntary and NMES indices of muscle contractility, such results are only moderately well-correlated at best. The two techniques should therefore be considered complementary rather than interchangeable.