A new Down syndrome rat model races forward

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nihms-1835764.pdf (39.67 KB)
Date
2022
Authors
Roper, Randall J.
Goodlett, Charles R.
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American English
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Biology, School of Science
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Elsevier
Abstract

Animal models of Down syndrome (DS) provide an essential resource for understanding genetic, cellular, and molecular contributions to traits associated with trisomy 21 (Ts21). Recent genetic enhancements in the development of DS models, including the new TcHSA21rat model (Kazuki et al.), have potential to transform our understanding of and potential therapies for Ts21.

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Trisomy, Animal models, Gene dosage, Neurodevelopment, Gene expression
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Roper RJ, Goodlett CR. A new Down syndrome rat model races forward. Trends Genet. 2022;38(11):1101-1102. doi:10.1016/j.tig.2022.05.001
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Trends in Genetics
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https://hdl.handle.net/1805/39915
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https://doi.org/10.1016/j.tig.2022.05.001
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