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    Cell-specific transcriptional signatures of vascular cells in Alzheimer’s disease: perspectives, pathways, and therapeutic directions
    (Springer Nature, 2025-01-29) Chaudhuri, Soumilee; Cho, Minyoung; Stumpff, Julia C; Bice, Paula J; İş, Özkan; Ertekin-Taner, Nilüfer; Saykin, Andrew J; Nho, Kwangsik
    Alzheimer’s disease (AD) is a debilitating neurodegenerative disease that is marked by profound neurovascular dysfunction and significant cell-specific alterations in the brain vasculature. Recent advances in high throughput single-cell transcriptomics technology have enabled the study of the human brain vasculature at an unprecedented depth. Additionally, the understudied niche of cerebrovascular cells, such as endothelial and mural cells, and their subtypes have been scrutinized for understanding cellular and transcriptional heterogeneity in AD. Here, we provide an overview of rich transcriptional signatures derived from recent single-cell and single-nucleus transcriptomic studies of human brain vascular cells and their implications for targeted therapy for AD. We conducted an in-depth literature search using Medline and Covidence to identify pertinent AD studies that utilized single-cell technologies in human post-mortem brain tissue by focusing on understanding the transcriptional differences in cerebrovascular cell types and subtypes in AD and cognitively normal older adults. We also discuss impaired cellular crosstalk between vascular cells and neuroglial units, as well as astrocytes in AD. Additionally, we contextualize the findings from single-cell studies of distinct endothelial cells, smooth muscle cells, fibroblasts, and pericytes in the human AD brain and highlight pathways for potential therapeutic interventions as a concerted multi-omic effort with spatial transcriptomics technology, neuroimaging, and neuropathology. Overall, we provide a detailed account of the vascular cell-specific transcriptional signatures in AD and their crucial cellular crosstalk with the neuroglial unit.
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    Accessibility assessment of the Midwest Chapter of MLA
    (2024-10-11) Pionke, JJ; Biszaha , Anna; Chrisagis, Ximena; DeCaro , Jessica; Feldman , Jennifer; Natal , Gerald; Regan , Matt; Gilbert Redman , Jessica D.; Shannon, Carol; Stumpff , Julia C.; Westall, Sara
    In 2023, JJ Pionke became the President of the Midwest Chapter of the Medical Library Association. He determined that for his presidential year, he would form a task force to determine the accessibility of the Chapter and remediate accessibility issues as appropriate. Case Presentation: To accomplish the accessibility audit of the organization, Pionke formed an Accessibility Task Force that was time limited to one year. Task force meetings were held once a month to keep people accountable and to share out progress and requests for assistance. The task force was broken up into four teams: annual meeting, policy, social media, and website. Task force members could be on more than one team. The goals of each team were generally the same: what are other organizations doing, what do we have already if anything, and develop best practices/policy/etc. as needed. Conclusions: The teams fulfilled their mandate by creating best practices/guidelines/policies documents. Some accessibility remediation was needed for the chapter website. The task force’s findings and materials were shared out among the Chapter as well as passed on to other Chapters, many of whom had expressed interest in our results.
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    Decision Fatigue in Hospital Settings: A Scoping Review
    (Wiley, 2024-11-11) Perry , Kelsey; Jones , Sarah; Stumpff, Julia C.; Kruer, Rachel; Czosnowski, Lauren; Kashiwagi, Deanne; Kara, Areeba
    BACKGROUND: ‘Decision Fatigue’ (DF) describes the impaired ability to make decisions because of repeated acts of decision-making. We conducted a scoping review to describe DF in inpatient settings. METHODS: To be included, studies should have explored a clinical decision, included a mechanism to account for the order of decision making, published in English in or after the year 2000. Six data bases were searched. Retrieved citations were screened and retained studies were reviewed against inclusion criteria. References of included studies were manually searched, and forward citation searches were conducted to capture relevant sources. RESULTS: The search retrieved 12,781 citations of which 41 were retained following screening. Following review, sixteen studies met inclusion criteria. Half were conference abstracts and no studies examined hospitalists. Emergency medicine and intensive care settings were the most frequently studied clinical environments (n=13, 81%). All studies were observational. The most frequently examined decisions were about resource utilization (n=8, 50%), however only half of these examined downstream clinical outcomes. Decision quality against prespecified standards was examined in four (25%) studies. Work environment and patient attributes were often described but not consistently accounted for in analyses. Clinician attributes were described in four (25%) investigations. Findings were inconsistent: both supporting and refuting DF’s role in the outcome studied. CONCLUSIONS: The role of clinician, patient and work environment attributes in mediating DF is understudied. Similarly, the contexts surrounding the decision under study require further explication and when assessing resource use and decision quality, adjudication should be made against prespecified standards.
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    Using searchRxiv for depositing evidence synthesis searches
    (2024-11-21) Craven, Hannah J.; Hinrichs, Rachel J.; Stumpff, Julia C.
    Librarians build detailed search strategies for evidence syntheses enabling the comprehensive retrieval of studies while taking care that no relevant studies are missed. However, this work may be wasted or lost if the review does not reach publication or if the search strategies are not included with the publication. Further, search strategies that are stored in article appendices may not be preserved in the long-term. To address these problems, we started depositing our evidence syntheses search strategies that we developed to a repository called searchRxiv (pronounced “search archive”); an open repository established by CABI Digital Library to support information professionals in reporting, sharing, re-using and preserving their searches. In this presentation, we will share our experience with searchRxiv, including the advantages and challenges of sharing search strategies as individual research products separate from reviews. For each challenge, we will share our lessons learned and solutions developed. We will also share pros and cons to using searchRxiv as opposed to a traditional institutional repository. Since 2022, we have been able to openly share 59 search strategies from 13 evidence syntheses using searchRxiv. Overall, we find searchRxiv to be a scalable approach for highlighting the unique contributions of librarians to evidence syntheses beyond publications, and for enabling re-use and reproducibility of our searches.
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    Oral History and Human Subject Research: A Roundtable and Community Conversation on the Current State of Risks, Regulations, and Ethics Reviews
    (2024-11-02) Bravent, Jay-Marie; Boyd, Douglas A.; Dilger, Kirsten; Pieczko, Brandon T.; Terry, Kopana
    The COVID-19 pandemic has highlighted the interconnections between public health research and oral history. The 2022 Nelson Memo and 2018 EU GDPR have raised awareness about research data, public access, retention, and transparency. As research protocols utilizing interview procedures have increased, so too have the risks associated with interviewees speaking publicly about political and social issues. Threats and targeting of ethnic groups, undocumented immigrants, libraries, and the LGBTQA+ community grow, along with worries about social media shaming or job loss for interviewees. AI. Deep fakes. Identity theft. As the importance of oral history in this shifting research context and public spotlight continues to grow, projects must increasingly adhere to data privacy protections, retention guidelines, transparency regulations, and ethics review. Social science and humanities research protocols must meet new criteria from peer-reviewed journals, Institutional Review Boards, institutional research and legal office reviews, federal agencies, and funding organizations. How can oral history researchers and practitioners adapt and support each other? How should interviewers prepare, train, and anticipate new levels of peer review and public scrutiny? How do we navigate the different legal and institutional interpretations of “exclusion” and “exemption”? All while preserving academic freedom and open repository access to oral history interviews? Join us for a discussion of the current state (and future) of oral history within the frameworks of human subject research review, data requirements, government regulations, cultural literacy guidelines, and best practices for ensuring protections for interviewees.
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    Mobilizing health equity through Computable Biomedical Knowledge (CBK): a call to action to the library, information sciences, and health informatics communities
    (Pitt Open Library, 2024) Allee, Nancy J.; Perry, Gerald; Rios, Gabriel R.; Rubin, Joshua C.; Subbian, Vignesh; Swain, Deborah E.; Wheeler, Terrie R.; Ruth Lilly Medical Library, School of Medicine
    The twin pandemics of COVID-19 and structural racism brought into focus health disparities and disproportionate impacts of disease on communities of color. Health equity has subsequently emerged as a priority. Recognizing that the future of health care will be informed by advanced information technologies including artificial intelligence (AI), machine learning, and algorithmic applications, the authors argue that to advance towards states of improved health equity, health information professionals need to engage in and encourage the conduct of research at the intersections of health equity, health disparities, and computational biomedical knowledge (CBK) applications. Recommendations are provided with a means to engage in this mobilization effort.
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    Pituitary Adenoma and Social Determinants of Health: Tracing PAths to Better Outcomes
    (2024-09-28) Virtanen , Piiamaria S.; Obeng-Gyasi, Barnabas; Brown, Ethan D. L.; Colter, Austyn; Koenig, Jenna; Burket, Noah; Szilagyi, Halie; Williams, Greer; Halalmeh, Dia; Wang, Hannah S.; Tinkham, Shawn A.; Vetter, Cecelia J.; Richardson, Angela M.
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    Online Scholarly Presence after Completing IMPRS
    (2024-06-11) Craven, Hannah J.; Pieczko, Brandon T.
    This handout is intended for IMPRS students to promote and claim their scholarly items online, increase visibility and findability of their work, and making it easier when they apply to residency using the Electronic Residency Application Service (ERAS).
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    Uploading your IMPRS Works to IU Indianapolis ScholarWorks
    (2024-06-11) Pieczko, Brandon T.; Craven, Hannah J.
    This handout is intended for people presenting at the IMPRS Research Symposium to assist with uploading their posters to IU Indianapolis ScholarWorks.
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    The Evolution of an Electronic Lab Notebook Community
    (2024-05-21) Dolan, Levi; Whipple, Elizabeth C.
    Electronic Lab Notebook (ELN) products are intended to replace physical lab notebooks in basic science and clinical research labs. As part of supporting rigor and reproducibility in biomedical research practices, our library supports ELN implementation at our institution. We investigated how ELNs are currently being implemented by analyzing backend ELN usage data, then used the results to reach out to super users. Based on their feedback, we created a shared electronic lab notebook with reusable components and sponsored a training event led by LabArchives product staff. This sequence of library outreach and programming activities has increased the library’s understanding of our ELN community and diversified our methods for advancing best practices in data management.