PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway-Deficient Acute Myeloid Leukemia

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dc.contributor.authorSheth, Aditya S.
dc.contributor.authorChan, Ka-Kui
dc.contributor.authorLiu, Sheng
dc.contributor.authorWan, Jun
dc.contributor.authorAngus, Steve P.
dc.contributor.authorRhodes, Steven D.
dc.contributor.authorMitchell, Dana K.
dc.contributor.authorDavis, Christopher
dc.contributor.authorRidinger, Maya
dc.contributor.authorCroucher, Peter J.
dc.contributor.authorZeidan, Amer M.
dc.contributor.authorWijeratne, Aruna
dc.contributor.authorQian, Shaomin
dc.contributor.authorTran, Ngoc Tung
dc.contributor.authorSierra Potchanant, Elizabeth A.
dc.contributor.departmentPediatrics, School of Medicine
dc.date.accessioned2025-05-13T11:39:46Z
dc.date.available2025-05-13T11:39:46Z
dc.date.issued2025
dc.description.abstractThis work demonstrates that FA pathway mutations, which are frequently observed in sporadic AML, induce hypersensitivity to PLK1 inhibition, providing rationale for a novel synthetic lethal therapeutic strategy for this patient population.
dc.eprint.versionFinal published version
dc.identifier.citationSheth AS, Chan KK, Liu S, et al. PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway-Deficient Acute Myeloid Leukemia. Cancer Res Commun. 2025;5(4):648-667. doi:10.1158/2767-9764.CRC-24-0260
dc.identifier.urihttps://hdl.handle.net/1805/48028
dc.language.isoen_US
dc.publisherAmerican Association for Cancer Research
dc.relation.isversionof10.1158/2767-9764.CRC-24-0260
dc.relation.journalCancer Research Communications
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePMC
dc.subjectCell cycle proteins
dc.subjectProtein serine-threonine kinases
dc.subjectProto-oncogene proteins
dc.subjectFanconi anemia
dc.titlePLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway-Deficient Acute Myeloid Leukemia
dc.typeArticle
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