PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway-Deficient Acute Myeloid Leukemia
Date
2025
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American English
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American Association for Cancer Research
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Abstract
This work demonstrates that FA pathway mutations, which are frequently observed in sporadic AML, induce hypersensitivity to PLK1 inhibition, providing rationale for a novel synthetic lethal therapeutic strategy for this patient population.
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Cite As
Sheth AS, Chan KK, Liu S, et al. PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway-Deficient Acute Myeloid Leukemia. Cancer Res Commun. 2025;5(4):648-667. doi:10.1158/2767-9764.CRC-24-0260
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Cancer Research Communications
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PMC
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Article
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Final published version