Pancreatic cancer-associated diabetes is an "exosomopathy"
| dc.contributor.author | Korc, Murray | |
| dc.contributor.department | Department of Medicine, IU School of Medicine | en_US |
| dc.date.accessioned | 2016-08-26T18:47:32Z | |
| dc.date.available | 2016-08-26T18:47:32Z | |
| dc.date.issued | 2015-04-01 | |
| dc.description.abstract | Diabetes may be a consequence of pancreatic cancer, preceding cancer diagnosis. The underlying mechanism is the release of exosomes delivering adrenomedullin to β cells, inducing endoplasmic reticulum stress and perturbations in the unfolded protein response, leading to β-cell dysfunction and death. This knowledge could lead to improved diagnostic strategies for pancreatic cancer. | en_US |
| dc.eprint.version | Author's manuscript | en_US |
| dc.identifier.citation | Korc, M. (2015). Pancreatic Cancer–Associated Diabetes Is an “Exosomopathy.” Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 21(7), 1508–1510. http://doi.org/10.1158/1078-0432.CCR-14-2990 | en_US |
| dc.identifier.issn | 1078-0432 | en_US |
| dc.identifier.uri | https://hdl.handle.net/1805/10778 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | American Association for Cancer Research | en_US |
| dc.relation.isversionof | 10.1158/1078-0432.CCR-14-2990 | en_US |
| dc.relation.journal | Clinical Cancer Research: An Official Journal of the American Association for Cancer Research | en_US |
| dc.rights | Publisher Policy | en_US |
| dc.source | PMC | en_US |
| dc.subject | Adrenomedullin | en_US |
| dc.subject | metabolism | en_US |
| dc.subject | Diabetes Mellitus | en_US |
| dc.subject | etiology | en_US |
| dc.subject | Exosomes | en_US |
| dc.subject | Insulin-Secreting Cells | en_US |
| dc.subject | Pancreatic Neoplasms | en_US |
| dc.subject | complications | en_US |
| dc.title | Pancreatic cancer-associated diabetes is an "exosomopathy" | en_US |
| dc.type | Article | en_US |