Pancreatic cancer-associated diabetes is an "exosomopathy"
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2015-04-01
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American English
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American Association for Cancer Research
Abstract
Diabetes may be a consequence of pancreatic cancer, preceding cancer diagnosis. The underlying mechanism is the release of exosomes delivering adrenomedullin to β cells, inducing endoplasmic reticulum stress and perturbations in the unfolded protein response, leading to β-cell dysfunction and death. This knowledge could lead to improved diagnostic strategies for pancreatic cancer.
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Korc, M. (2015). Pancreatic Cancer–Associated Diabetes Is an “Exosomopathy.” Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 21(7), 1508–1510. http://doi.org/10.1158/1078-0432.CCR-14-2990
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1078-0432
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Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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PMC
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