Turmeric Extract Rescues Ethanol‐Induced Developmental Defect in the Zebrafish Model for Fetal Alcohol Spectrum Disorder (FASD)

dc.contributor.authorMuralidharan, Pooja
dc.contributor.authorConnors, Craig
dc.contributor.authorMohammed, Arooj S.
dc.contributor.authorSarmah, Swapnalee
dc.contributor.authorMarrs, Kathleen A.
dc.contributor.authorMarrs, James A.
dc.contributor.authorChism, Grady W.
dc.contributor.departmentBiology, School of Scienceen_US
dc.date.accessioned2018-04-06T17:27:49Z
dc.date.available2018-04-06T17:27:49Z
dc.date.issued2017
dc.description.abstractPrenatal ethanol exposure causes the most frequent preventable birth disorder, fetal alcohol spectrum disorder (FASD). The effect of turmeric extracts in rescuing an ethanol‐induced developmental defect using zebrafish as a model was determined. Ethanol‐induced oxidative stress is one of the major mechanisms underlying FASD. We hypothesize that antioxidant inducing properties of turmeric may alleviate ethanol‐induced defects. Curcuminoid content of the turmeric powder extract (5 mg/mL turmeric in ethanol) was determined by UPLC and found to contain Curcumin (124.1 ± 0.2 μg/mL), Desmethoxycurcumin (43.4 ± 0.1 μg/mL), and Bisdemethoxycurcumin (36.6 ± 0.1 μg/mL). Zebrafish embryos were treated with 100 mM (0.6% v/v) ethanol during gastrulation through organogenesis (2 to 48 h postfertilization (hpf)) and supplemented with turmeric extract to obtain total curcuminoid concentrations of 0, 1.16, 1.72, or 2.32 μM. Turmeric supplementation showed significant rescue of the body length at 72 hpf compared to ethanol‐treated embryos. The mechanism underlying the rescue remains to be determined.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationMuralidharan Pooja, Connors Craig T., Mohammed Arooj S., Sarmah Swapnalee, Marrs Kathleen, Marrs James A., & Chism Grady W. (2017). Turmeric Extract Rescues Ethanol‐Induced Developmental Defect in the Zebrafish Model for Fetal Alcohol Spectrum Disorder (FASD). Journal of Food Science, 82(9), 2221–2225. https://doi.org/10.1111/1750-3841.13830en_US
dc.identifier.urihttps://hdl.handle.net/1805/15789
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1111/1750-3841.13830en_US
dc.relation.journalJournal of Food Scienceen_US
dc.rightsPublisher Policyen_US
dc.sourceAuthoren_US
dc.subjectturmeric extracten_US
dc.subjectfetal alcohol spectrum disorderen_US
dc.subjectprenatal ethanol exposureen_US
dc.titleTurmeric Extract Rescues Ethanol‐Induced Developmental Defect in the Zebrafish Model for Fetal Alcohol Spectrum Disorder (FASD)en_US
dc.typeArticleen_US
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