Does miRNA-155 Promote Cyclooxygenase-2 Expression in Cancer?

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dc.contributor.authorComer, Brian S.
dc.contributor.departmentDepartment of Cellular and Integrative Physiology, IU School of Medicineen_US
dc.date.accessioned2016-05-06T15:19:17Z
dc.date.available2016-05-06T15:19:17Z
dc.date.issued2015-11
dc.description.abstractMicroRNA (miR)-155 and cyclooxygenase (COX)-2 are both elevated in numerous cancers including colorectal cancer. MiR-155 enhances COX-2 expression and is an established regulator of epithelial-mesenchymal transition and inflammation. Inhibition of miR-155 or COX-2 exhibit similar negative effects on tumorigenicity. Thus, it is hypothesized that miR-155 may be a promising target for antagonizing COX-2 expression in colorectal and other cancers.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationComer, B. S. (2015). Does miRNA-155 Promote Cyclooxygenase-2 Expression in Cancer? Drug Development Research, 76(7), 354–356. http://doi.org/10.1002/ddr.21276en_US
dc.identifier.urihttps://hdl.handle.net/1805/9543
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/ddr.21276en_US
dc.relation.journalDrug Development Researchen_US
dc.rightsPublisher Policyen_US
dc.sourceAuthoren_US
dc.subjectBICen_US
dc.subjectPTGS-2en_US
dc.subjectMicroRNA-155en_US
dc.subjectcanceren_US
dc.titleDoes miRNA-155 Promote Cyclooxygenase-2 Expression in Cancer?en_US
dc.typeArticleen_US
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