Role of STAT3 pathway in genitourinary tumors

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dc.contributor.authorSantoni, Matteo
dc.contributor.authorConti, Alessandro
dc.contributor.authorPiva, Francesco
dc.contributor.authorMassari, Francesco
dc.contributor.authorCiccarese, Chiara
dc.contributor.authorBurattini, Luciano
dc.contributor.authorCheng, Liang
dc.contributor.authorLopez-Beltran, Antonio
dc.contributor.authorScarpelli, Marina
dc.contributor.authorSantini, Daniele
dc.contributor.authorTortora, Giampaolo
dc.contributor.authorCascinu, Stefano
dc.contributor.authorMontironi, Rodolfo
dc.contributor.departmentDepartment of Pathology and Laboratory Medicine, IU School of Medicineen_US
dc.date.accessioned2017-06-19T17:46:47Z
dc.date.available2017-06-19T17:46:47Z
dc.date.issued2015-11-01
dc.description.abstractThe STAT3 is often dysregulated in genitourinary tumors. In prostate cancer, STAT3 activation correlates with Gleason score and pathological stage and modulates cancer stem cells and epithelial-mesenchymal transition. In addition, STAT3 promotes the progression from carcinoma in situ to invasive bladder cancer and modulates renal cell carcinoma angiogenesis by increasing the expression of HIF1α and VEGF. STAT3 is also involved in the response to tyrosine kinase inhibitors sunitinib and axitinib, in patients with metastatic renal cell carcinoma, and to second-generation androgen receptor inhibitor enzalutamide in patients with advanced prostate cancer. In this review, we describe the role of STAT3 in genitourinary tumors, thus describing its potential for future therapeutic strategies.en_US
dc.identifier.citationSantoni, M., Conti, A., Piva, F., Massari, F., Ciccarese, C., Burattini, L., … Montironi, R. (2015). Role of STAT3 pathway in genitourinary tumors. Future Science OA, 1(3), FSO15. http://doi.org/10.4155/fso.15.13en_US
dc.identifier.urihttps://hdl.handle.net/1805/13094
dc.language.isoen_USen_US
dc.publisherFuture Science Groupen_US
dc.relation.isversionof10.4155/fso.15.13en_US
dc.relation.journalFuture Science OAen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/
dc.sourcePMCen_US
dc.subjectDrug resistanceen_US
dc.subjectGenitourinary tumorsen_US
dc.subjectMetastasisen_US
dc.subjectSignal transducer and activator of transcription 3en_US
dc.subjectTumor microenvironmenten_US
dc.titleRole of STAT3 pathway in genitourinary tumorsen_US
dc.typeArticleen_US
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