Role of STAT3 pathway in genitourinary tumors

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Date
2015-11-01
Authors
Santoni, Matteo
Conti, Alessandro
Piva, Francesco
Massari, Francesco
Ciccarese, Chiara
Burattini, Luciano
Cheng, Liang
Lopez-Beltran, Antonio
Scarpelli, Marina
Santini, Daniele
Tortora, Giampaolo
Cascinu, Stefano
Montironi, Rodolfo
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American English
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Department of Pathology and Laboratory Medicine, IU School of Medicine
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Future Science Group
Abstract

The STAT3 is often dysregulated in genitourinary tumors. In prostate cancer, STAT3 activation correlates with Gleason score and pathological stage and modulates cancer stem cells and epithelial-mesenchymal transition. In addition, STAT3 promotes the progression from carcinoma in situ to invasive bladder cancer and modulates renal cell carcinoma angiogenesis by increasing the expression of HIF1α and VEGF. STAT3 is also involved in the response to tyrosine kinase inhibitors sunitinib and axitinib, in patients with metastatic renal cell carcinoma, and to second-generation androgen receptor inhibitor enzalutamide in patients with advanced prostate cancer. In this review, we describe the role of STAT3 in genitourinary tumors, thus describing its potential for future therapeutic strategies.

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Keywords
Drug resistance, Genitourinary tumors, Metastasis, Signal transducer and activator of transcription 3, Tumor microenvironment
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Santoni, M., Conti, A., Piva, F., Massari, F., Ciccarese, C., Burattini, L., … Montironi, R. (2015). Role of STAT3 pathway in genitourinary tumors. Future Science OA, 1(3), FSO15. http://doi.org/10.4155/fso.15.13
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Future Science OA
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Attribution-NonCommercial-NoDerivs 3.0 United States Creative Commons licenses
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https://hdl.handle.net/1805/13094
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https://doi.org/10.4155/fso.15.13
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