Asparagine, a critical limiting metabolite during glutamine starvation

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dc.contributor.authorJiang, Jie
dc.contributor.authorPavlova, Natalya N.
dc.contributor.authorZhang, Ji
dc.contributor.departmentPediatrics, School of Medicineen_US
dc.date.accessioned2019-08-05T15:16:58Z
dc.date.available2019-08-05T15:16:58Z
dc.date.issued2018-04-11
dc.description.abstractA challenge of targeting glutamine metabolism in cancer is that tumor cells develop various strategies to adapt to glutamine limitation. We found that asparagine plays a critical role in supporting protein synthesis during glutamine starvation, highlighting a possible approach to optimize the therapeutic efficacy of targeting glutamine metabolism in cancer.en_US
dc.identifier.citationJiang, J., Pavlova, N. N., & Zhang, J. (2018). Asparagine, a critical limiting metabolite during glutamine starvation. Molecular & cellular oncology, 5(3), e1441633. doi:10.1080/23723556.2018.1441633en_US
dc.identifier.urihttps://hdl.handle.net/1805/20176
dc.language.isoen_USen_US
dc.publisherTaylor & Francisen_US
dc.relation.isversionof10.1080/23723556.2018.1441633en_US
dc.relation.journalMolecular & Cellular Oncologyen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/us*
dc.sourcePMCen_US
dc.subjectGlutamineen_US
dc.subjectAsparagineen_US
dc.subjectAsparaginaseen_US
dc.subjectGlutamine synthetaseen_US
dc.subjectProtein synthesisen_US
dc.subjectBiology of malignant cellsen_US
dc.subjectMechanisms of oncogenesis and tumor progressionen_US
dc.subjectNovel therapeutic targetsen_US
dc.subjectOncogenes and tumor suppressor genesen_US
dc.subjectTumor metabolismen_US
dc.titleAsparagine, a critical limiting metabolite during glutamine starvationen_US
dc.typeArticleen_US
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