Asparagine, a critical limiting metabolite during glutamine starvation

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Date
2018-04-11
Authors
Jiang, Jie
Pavlova, Natalya N.
Zhang, Ji
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American English
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Pediatrics, School of Medicine
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Taylor & Francis
Abstract

A challenge of targeting glutamine metabolism in cancer is that tumor cells develop various strategies to adapt to glutamine limitation. We found that asparagine plays a critical role in supporting protein synthesis during glutamine starvation, highlighting a possible approach to optimize the therapeutic efficacy of targeting glutamine metabolism in cancer.

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Keywords
Glutamine, Asparagine, Asparaginase, Glutamine synthetase, Protein synthesis, Biology of malignant cells, Mechanisms of oncogenesis and tumor progression, Novel therapeutic targets, Oncogenes and tumor suppressor genes, Tumor metabolism
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Jiang, J., Pavlova, N. N., & Zhang, J. (2018). Asparagine, a critical limiting metabolite during glutamine starvation. Molecular & cellular oncology, 5(3), e1441633. doi:10.1080/23723556.2018.1441633
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Molecular & Cellular Oncology
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Attribution-NonCommercial-NoDerivs 3.0 United States Creative Commons licenses
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PMC
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https://hdl.handle.net/1805/20176
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https://doi.org/10.1080/23723556.2018.1441633
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