Less cholesterol means better tumor killing for cytotoxic T9 cells

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Date
2018-06-04
Authors
Griesenauer, Brad
Paczesny, Sophie
Language
American English
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Pediatrics, School of Medicine
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Rockefeller University Press
Abstract

In this issue, Ma et al. (https://doi.org/10.1084/jem.20171576) show that removal of cholesterol from CD8 T cells during type 9 differentiation increases their IL-9 production, persistence in vivo, and cytolytic function against tumors by preventing SUMOylation of liver X receptors.

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Cholesterol, CD8 T cells, Type 9 differentiation, IL-9 production, Liver X receptors
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Griesenauer, B., & Paczesny, S. (2018). Less cholesterol means better tumor killing for cytotoxic T9 cells. The Journal of experimental medicine, 215(6), 1505–1506. doi:10.1084/jem.20180852
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The Journal of Experimental Medicine
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Attribution-NonCommercial-NoDerivs 3.0 United States Creative Commons licenses
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PMC
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https://hdl.handle.net/1805/19452
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https://doi.org/10.1084/jem.20180852
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