Comparison of outcomes in patients with intracranial hemorrhage on factor Xa inhibitors versus vitamin K antagonists treated with 4-factor prothrombin complex concentrate
dc.contributor.author | Harrison, Sarah K. | |
dc.contributor.author | Garrett, John S. | |
dc.contributor.author | Kohman, Kelsey N. | |
dc.contributor.author | Kline, Jeffrey A. | |
dc.contributor.department | Emergency Medicine, School of Medicine | en_US |
dc.date.accessioned | 2018-08-07T20:57:13Z | |
dc.date.available | 2018-08-07T20:57:13Z | |
dc.date.issued | 2018-04-11 | |
dc.description.abstract | The relative clinical efficacy of 4-factor prothrombin complex concentrate (4F-PCC) in oral anticoagulant-associated intracranial hemorrhage is unknown, especially for factor Xa-inhibiting anticoagulants. We report short-term outcomes of patients with oral anticoagulant-associated intracranial hemorrhage on vitamin K antagonists and factor Xa inhibitors who were treated with 4F-PCC. This multicenter, observational study involved patients presenting to the emergency department in nine hospitals in an integrated health care delivery system in Texas between July 2013 and December 2015. Forty-two patients diagnosed with oral anticoagulant-associated intracranial hemorrhage-24 taking a vitamin K antagonist and 14 taking a factor Xa inhibitor-were treated with 4F-PCC as part of usual care. Study patients had similar baseline demographics, with the exception of suspected etiology of hemorrhage. Outcomes of the vitamin K antagonist group were similar to those of the factor Xa inhibitor group, with no significant differences in overall in-hospital mortality (32.1% vs 14.2%, respectively), length of stay, or rates of hemorrhagic expansion, thromboembolism, or discharge to home. In conclusion, this small sample of patients with oral factor Xa inhibitor and vitamin K antagonist-associated intracranial hemorrhage treated with 4F-PCC had similar mortality and neurological outcomes, with no venous thromboembolic events. | en_US |
dc.eprint.version | Final published version | en_US |
dc.identifier.citation | Harrison, S. K., Garrett, J. S., Kohman, K. N., & Kline, J. A. (2018). Comparison of outcomes in patients with intracranial hemorrhage on factor Xa inhibitors versus vitamin K antagonists treated with 4-factor prothrombin complex concentrate. Proceedings (Baylor University. Medical Center), 31(2), 153–156. http://doi.org/10.1080/08998280.2018.1440858 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/17020 | |
dc.language.iso | en_US | en_US |
dc.publisher | Taylor & Francis | en_US |
dc.relation.isversionof | 10.1080/08998280.2018.1440858 | en_US |
dc.relation.journal | Proceedings (Baylor University. Medical Center) | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | 4-factor prothrombin complex concentrate | en_US |
dc.subject | Emergent reversal | en_US |
dc.subject | Fresh frozen plasma | en_US |
dc.subject | Intracranial hemorrhage | en_US |
dc.subject | Oral anticoagulation | en_US |
dc.title | Comparison of outcomes in patients with intracranial hemorrhage on factor Xa inhibitors versus vitamin K antagonists treated with 4-factor prothrombin complex concentrate | en_US |
dc.type | Article | en_US |
ul.alternative.fulltext | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914465/ | en_US |
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