Age-related differences in conditioned pain modulation of sensitizing and desensitizing trends during response dependent stimulation

dc.contributor.authorNaugle, Kelly M.
dc.contributor.authorCruz-Almeida, Yenisel
dc.contributor.authorVierck, Charles J.
dc.contributor.authorMauderli, Andre P.
dc.contributor.authorRiley III, Joseph L.
dc.contributor.departmentDepartment of Kinesiology, School of Physical Education and Tourism Managementen_US
dc.date.accessioned2017-05-24T18:45:28Z
dc.date.available2017-05-24T18:45:28Z
dc.date.issued2015-08
dc.description.abstractThe current study evaluated age differences in conditioned pain modulation using a test stimulus that provided the opportunity to evaluate changes in heat pain sensitivity, sensitization, and desensitization within the same paradigm. During this psychophysical test, pain intensity clamping uses REsponse Dependent STIMulation (REDSTIM) methodology to automatically adjust stimulus intensity to maintain a desired pain rating set-point. Specifically, stimulus intensity increases until a pre-defined pain rating (the setpoint) is exceeded, and then decreases until pain ratings fall below the setpoint, with continued increases and decreases dictated by ratings. The subjects are blinded in terms of the setpoint and stimulus intensities. Younger and older subjects completed two test sessions of two REDSTIM trials, with presentation of conditioning cold stimulation between the trials of one session but not the other. The results indicated that conditioning cold stimulation similarly decreased the overall sensitivity of younger and older subjects, as measured by the average temperature that maintained a setpoint rating of 20 (on a scale of 0-100). The conditioning stimulus also significantly enhanced sensitization following ascending stimulus progressions and desensitization following descending stimulus progressions in older subjects relative to younger subjects. Thus, older subjects experienced greater swings in sensitivity in response to varying levels of painful stimulation. These results are discussed in terms of control over pain intensity by descending central modulatory systems. These findings potentially shed new light on the central control over descending inhibition and facilitation of pain.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationNaugle, K. M., Cruz-Almeida, Y., Vierck, C. J., Mauderli, A. P., & Riley, J. L. (2015). Age-related differences in conditioned pain modulation of sensitizing and desensitizing trends during response dependent stimulation. Behavioural Brain Research, 289, 61–68. http://doi.org/10.1016/j.bbr.2015.04.014en_US
dc.identifier.urihttps://hdl.handle.net/1805/12718
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.bbr.2015.04.014en_US
dc.relation.journalBehavioural Brain Researchen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectOlder adultsen_US
dc.subjectPain inhibitionen_US
dc.subjectPain modulationen_US
dc.subjectResponse dependent stimulation (REDSTIM)en_US
dc.subjectPain sensitivityen_US
dc.subjectAgingen_US
dc.titleAge-related differences in conditioned pain modulation of sensitizing and desensitizing trends during response dependent stimulationen_US
dc.typeArticleen_US
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