Thymic Carcinomas and Second Malignancies: A Single-Center Review

dc.contributor.authorBadve, Sunil S.
dc.contributor.authorDougherty, Rachel
dc.contributor.authorBalatico, Michael
dc.contributor.authorKesler, Kenneth A.
dc.contributor.authorLoehrer, Patrick
dc.contributor.authorGökmen-Polar, Yesim
dc.contributor.departmentSurgery, School of Medicineen_US
dc.date.accessioned2022-09-19T16:39:47Z
dc.date.available2022-09-19T16:39:47Z
dc.date.issued2021-05-19
dc.description.abstractThymic carcinomas account for less than 0.01% of new cancer diagnoses annually and are more aggressive than thymomas. Autoimmune disorders have been associated with thymomas and only recently with thymic carcinomas. Second malignancies are well described after thymomas. The aim of this study was to analyze the incidence of second malignancies in patients with thymic carcinomas. All cases of thymic carcinomas were identified from the pathology archives of Indiana University. Histological materials were reviewed and further correlated with clinical data to identify incidence of second cancers in patients with thymic carcinomas. Histological material was available for review in 92 cases of thymic carcinoma. Clinical data were available for 85 patients. Fourteen of these (16.5%) patients had a second malignancy; these included small cell lung carcinoma, "testicular cancer", embryonal carcinoma, seminoma, breast carcinoma (two cases), prostatic adenocarcinoma, Hodgkin's lymphoma, thyroid carcinoma, bladder carcinoma (two cases), renal cell carcinoma, and melanoma. The latter could precede, be concurrent with, or follow the diagnosis thymic carcinoma. The incidence of second cancers in patients with thymic carcinomas is similar to that reported for thymomas. Abnormalities in immunological surveillance may be responsible for this high incidence of second malignancies in thymic tumors.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationBadve SS, Dougherty R, Balatico M, Kesler KA, Loehrer P, Gökmen-Polar Y. Thymic Carcinomas and Second Malignancies: A Single-Center Review. Cancers (Basel). 2021;13(10):2472. Published 2021 May 19. doi:10.3390/cancers13102472en_US
dc.identifier.urihttps://hdl.handle.net/1805/30048
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.isversionof10.3390/cancers13102472en_US
dc.relation.journalCancersen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0*
dc.sourcePMCen_US
dc.subjectImmune surveillanceen_US
dc.subjectSecond cancersen_US
dc.subjectThymic canceren_US
dc.titleThymic Carcinomas and Second Malignancies: A Single-Center Reviewen_US
dc.typeArticleen_US
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