Development, validation and implementation of radio-HPLC methods for the P2X7-receptor-targeted [11C]GSK1482160 radiopharmaceutical

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dc.contributor.authorWissman, Carmen L.
dc.contributor.authorWang, Min
dc.contributor.authorGao, Mingzhang
dc.contributor.authorZheng, Qi-Huang
dc.contributor.authorGreen, Mark A.
dc.contributor.departmentRadiology and Imaging Sciences, School of Medicineen_US
dc.date.accessioned2018-10-19T19:23:38Z
dc.date.available2018-10-19T19:23:38Z
dc.date.issued2018-12
dc.description.abstractA radio-analytical RP-HPLC method was developed and validated to support production of the P2X7-receptor-targeted [11C]GSK1482160 radiopharmaceutical. Method validation included characterization of retention times, peak shapes, linearity, accuracy, precision, selectivity, limits of detection and quantitation (UV signal), radiochemical stability, as well as analytical method range and robustness. The validated radio-HPLC method is suitable for the definition of [11C]GSK1482160 radiochemical identity, radiochemical purity, as well as molar activity, and is being employed in support of human studies with [11C]GSK1482160.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationWissmann, C. L., Wang, M., Gao, M., Zheng, Q.-H., & Green, M. A. (2018). Development, validation and implementation of radio-HPLC methods for the P2X7-receptor-targeted [11C]GSK1482160 radiopharmaceutical. Applied Radiation and Isotopes, 142, 8–11. https://doi.org/10.1016/j.apradiso.2018.09.007en_US
dc.identifier.urihttps://hdl.handle.net/1805/17617
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.apradiso.2018.09.007en_US
dc.relation.journalApplied Radiation and Isotopesen_US
dc.rightsPublisher Policyen_US
dc.sourceAuthoren_US
dc.subject[11C]GSK1482160en_US
dc.subjectradio-analytical HPLC methoden_US
dc.subjectinflammationen_US
dc.titleDevelopment, validation and implementation of radio-HPLC methods for the P2X7-receptor-targeted [11C]GSK1482160 radiopharmaceuticalen_US
dc.typeArticleen_US
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