Development, validation and implementation of radio-HPLC methods for the P2X7-receptor-targeted [11C]GSK1482160 radiopharmaceutical
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Date
2018-12
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English
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Elsevier
Abstract
A radio-analytical RP-HPLC method was developed and validated to support production of the P2X7-receptor-targeted [11C]GSK1482160 radiopharmaceutical. Method validation included characterization of retention times, peak shapes, linearity, accuracy, precision, selectivity, limits of detection and quantitation (UV signal), radiochemical stability, as well as analytical method range and robustness. The validated radio-HPLC method is suitable for the definition of [11C]GSK1482160 radiochemical identity, radiochemical purity, as well as molar activity, and is being employed in support of human studies with [11C]GSK1482160.
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Wissmann, C. L., Wang, M., Gao, M., Zheng, Q.-H., & Green, M. A. (2018). Development, validation and implementation of radio-HPLC methods for the P2X7-receptor-targeted [11C]GSK1482160 radiopharmaceutical. Applied Radiation and Isotopes, 142, 8–11. https://doi.org/10.1016/j.apradiso.2018.09.007
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Applied Radiation and Isotopes
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