Pre-Diagnostic Telomere Length and Colorectal Cancer Risk

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dc.contributor.authorYang, Keming
dc.contributor.authorPrescott, Jennifer
dc.contributor.authorHazra, Aditi
dc.contributor.authorMeyerhardt, Jeffrey A.
dc.contributor.authorZhang, Xuehong
dc.contributor.authorDe Vivo, Immaculata
dc.contributor.authorChan, Andrew T.
dc.contributor.authorDu, Mengmeng
dc.contributor.authorGiovannucci, Edward L.
dc.contributor.authorNan, Hongmei
dc.contributor.departmentCommunity and Global Health, Richard M. Fairbanks School of Public Health
dc.date.accessioned2024-04-30T12:14:01Z
dc.date.available2024-04-30T12:14:01Z
dc.date.issued2022
dc.description.abstractBackground: Progressive telomere shortening may be related to genomic instability and carcinogenesis. Prospective evidence relating telomere length (TL) with colorectal cancer (CRC) risk has been limited and inconsistent. Methods: We examined the association between pre-diagnostic peripheral blood leukocyte TL and CRC risk in two matched case-control studies nested within the Nurses' Health Study (NHS) and the Health Professionals Follow-Up Study (HPFS). Relative leukocyte TL was measured using qPCR among 356 incident CRC cases and 801 controls (NHS: 186/465, HPFS: 170/336). Results: We did not find a significant association between pre-diagnostic TL and CRC risk [in all participants, multivariable-adjusted odds ratio (OR) (95% CI) for TL Quartile 1 (shortest) vs. Quartile 4 (longest) = 1.36 (0.85, 2.17), P-trend = 0.27; OR (95% CI) per 1 SD decrease in TL = 1.12 (0.92, 1.36)]. Conclusions: Our prospective analysis did not support a significant association between pre-diagnostic leukocyte TL and CRC risk.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationYang K, Prescott J, Hazra A, et al. Pre-diagnostic telomere length and colorectal cancer risk. Cancer Epidemiol. 2022;77:102100. doi:10.1016/j.canep.2022.102100
dc.identifier.urihttps://hdl.handle.net/1805/40356
dc.language.isoen_US
dc.publisherElsevier
dc.relation.isversionof10.1016/j.canep.2022.102100
dc.relation.journalCancer Epidemiology
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectTelomere length
dc.subjectPeripheral blood leukocyte
dc.subjectColorectal cancer
dc.subjectColon cancer
dc.subjectRectal cancer
dc.subjectNested case-control study
dc.titlePre-Diagnostic Telomere Length and Colorectal Cancer Risk
dc.typeArticle
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