A validated measure of adherence to antibiotic prophylaxis in children with sickle cell disease

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Date
2016
Authors
Duncan, Natalie A.
Kronenberger, William G.
Hampton, Kisha C.
Bloom, Ellen M.
Rampersad, Angeli G.
Roberson, Christopher P.
Shapiro, Amy D.
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American English
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Department of Psychiatry, IU School of Medicine
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Dove Medical Press
Abstract

BACKGROUND: Antibiotic prophylaxis is a mainstay in sickle cell disease management. However, adherence is estimated at only 66%. This study aimed to develop and validate a Sickle Cell Antibiotic Adherence Level Evaluation (SCAALE) to promote systematic and detailed adherence evaluation. METHODS: A 28-item questionnaire was created, covering seven adherence areas. General Adherence Ratings from the parent and one health care provider and medication possession ratios were obtained as validation measures. RESULTS: Internal consistency was very good to excellent for the total SCAALE (α=0.89) and four of the seven subscales. Correlations between SCAALE scores and validation measures were strong for the total SCAALE and five of the seven subscales. CONCLUSION: The SCAALE provides a detailed, quantitative, multidimensional, and global measurement of adherence and can promote clinical care and research.

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Keywords
SCAALE, Sickle SAFE Program, compliance, hemoglobinopathy, newborn screening program, penicillin prophylaxis
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Duncan, N. A., Kronenberger, W. G., Hampton, K. C., Bloom, E. M., Rampersad, A. G., Roberson, C. P., & Shapiro, A. D. (2016). A validated measure of adherence to antibiotic prophylaxis in children with sickle cell disease. Patient Preference and Adherence, 10, 983–992. http://doi.org/10.2147/PPA.S103874
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Patient Preference and Adherence
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PMC
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https://hdl.handle.net/1805/12184
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https://doi.org/10.2147/PPA.S103874
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Final published version
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