3D Mapping Reveals a Complex and Transient Interstitial Matrix During Murine Kidney Development

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dc.contributor.authorLipp, Sarah N.
dc.contributor.authorJacobson, Kathryn R.
dc.contributor.authorHains, David S.
dc.contributor.authorSchwarderer, Andrew L.
dc.contributor.authorCalve, Sarah
dc.contributor.departmentPediatrics, School of Medicine
dc.date.accessioned2024-04-02T10:06:28Z
dc.date.available2024-04-02T10:06:28Z
dc.date.issued2021
dc.description.abstractESKD is increasing in incidence and a limited number of organs are available for transplantation. Therefore, researchers have focused on understanding how cellular signaling influences kidney development to expand strategies to rebuild a kidney. However, the extracellular matrix (ECM), another critical component that biomechanically regulates nephrogenesis, has been largely neglected. Proteomics and 3D imaging of the murine kidney resolved previously undescribed dynamics of the interstitial matrix in the cortex and corticomedullary junction during development. Combined with cells and growth factors, scaffolds modeled after the composition and organization of the developmental ECM have the potential to improve engineered models of the kidney.
dc.identifier.citationLipp SN, Jacobson KR, Hains DS, Schwarderer AL, Calve S. 3D Mapping Reveals a Complex and Transient Interstitial Matrix During Murine Kidney Development. J Am Soc Nephrol. 2021;32(7):1649-1665. doi:10.1681/ASN.2020081204
dc.identifier.urihttps://hdl.handle.net/1805/39671
dc.language.isoen_US
dc.publisherWolters Kluwer
dc.relation.isversionof10.1681/ASN.2020081204
dc.relation.journalJournal of the American Society of Nephrology
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectInterstitial matrix
dc.subjectBasement membrane
dc.subjectMass spectrometry
dc.subject3D imaging
dc.subjectKidney development
dc.subjectExtracellular matrix
dc.subjectKidney anatomy
dc.title3D Mapping Reveals a Complex and Transient Interstitial Matrix During Murine Kidney Development
dc.typeArticle
ul.alternative.fulltexthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425666/
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