Alzheimer's disease genetic risk variants beyond APOE ε4 predict mortality

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dc.contributor.authorMez, Jesse
dc.contributor.authorMarden, Jessica R.
dc.contributor.authorMukherjee, Shubhabrata
dc.contributor.authorWalter, Stefan
dc.contributor.authorGibbons, Laura E.
dc.contributor.authorGross, Alden L.
dc.contributor.authorZahodne, Laura B.
dc.contributor.authorGilsanz, Paola
dc.contributor.authorBrewster, Paul
dc.contributor.authorNho, Kwangsik
dc.contributor.authorCrane, Paul K.
dc.contributor.authorLarson, Eric B.
dc.contributor.authorGlymour, M. Maria
dc.contributor.departmentRadiology and Imaging Sciences, School of Medicineen_US
dc.date.accessioned2018-03-14T17:54:34Z
dc.date.available2018-03-14T17:54:34Z
dc.date.issued2017-08-24
dc.description.abstract• A genetic risk score from 21 non-APOE late-onset Alzheimer's disease risk variants predicts mortality. • The genetic risk score likely confers risk for mortality through its effect on dementia incidence. • Late-onset Alzheimer's disease risk loci effect estimates from genome-wide association unlikely suffer from selection bias.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationMez, J., Marden, J. R., Mukherjee, S., Walter, S., Gibbons, L. E., Gross, A. L., … Glymour, M. M. (2017). Alzheimer’s disease genetic risk variants beyond APOE ε4 predict mortality. Alzheimer’s & Dementia : Diagnosis, Assessment & Disease Monitoring, 8, 188–195. https://doi.org/10.1016/j.dadm.2017.07.002en_US
dc.identifier.issn2352-8729en_US
dc.identifier.urihttps://hdl.handle.net/1805/15539
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.dadm.2017.07.002en_US
dc.relation.journalAlzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoringen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/
dc.sourcePMCen_US
dc.subjectAPOEen_US
dc.subjectAdult Changes in Thought (ACT)en_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectCohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)en_US
dc.subjectCollider stratification biasen_US
dc.subjectGenetic risk scoreen_US
dc.subjectenome-wide association study (GWAS)en_US
dc.subjectHealth and Retirement Study (HRS)en_US
dc.subjectLongevityen_US
dc.subjectMortalityen_US
dc.subjectSelection biasen_US
dc.subjectSurvival analysisen_US
dc.subjectSurvivor biasen_US
dc.titleAlzheimer's disease genetic risk variants beyond APOE ε4 predict mortalityen_US
dc.typeArticleen_US
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