Alzheimer's disease genetic risk variants beyond APOE ε4 predict mortality

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Date
2017-08-24
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American English
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Elsevier
Abstract

• A genetic risk score from 21 non-APOE late-onset Alzheimer's disease risk variants predicts mortality.

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          The genetic risk score likely confers risk for mortality through its effect on dementia incidence.
        
        
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          Late-onset Alzheimer's disease risk loci effect estimates from genome-wide association unlikely suffer from selection bias.
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Mez, J., Marden, J. R., Mukherjee, S., Walter, S., Gibbons, L. E., Gross, A. L., … Glymour, M. M. (2017). Alzheimer’s disease genetic risk variants beyond APOE ε4 predict mortality. Alzheimer’s & Dementia : Diagnosis, Assessment & Disease Monitoring, 8, 188–195. https://doi.org/10.1016/j.dadm.2017.07.002
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2352-8729
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Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
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PMC
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