Targeted Protein Detection using an All-In-One Mass Spectrometry Cartridge
| dc.contributor.author | Zhang, Chengsen | |
| dc.contributor.author | Glaros, Trevor | |
| dc.contributor.author | Manicke, Nicholas E. | |
| dc.contributor.department | Chemistry and Chemical Biology, School of Science | en_US |
| dc.date.accessioned | 2018-03-23T14:28:12Z | |
| dc.date.available | 2018-03-23T14:28:12Z | |
| dc.date.issued | 2017-07 | |
| dc.description.abstract | We developed a simple 3D printed cartridge for mass spectrometry (MS) targeted detection of plasma proteins, including post-translational modifications (PTMs). The cartridge uses an integrated antibody enrichment column to preconcentrate the protein target as well as a novel built-in substrate to ionize the protein targets for MS detection. We show several examples of using this cartridge to perform rapid detection of clinically significant proteoforms from plasma samples. | en_US |
| dc.eprint.version | Author's manuscript | en_US |
| dc.identifier.citation | Zhang, C., Glaros, T., & Manicke, N. E. (2017). Targeted Protein Detection Using an All-in-One Mass Spectrometry Cartridge. Journal of the American Chemical Society, 139(32), 10996–10999. https://doi.org/10.1021/jacs.7b05571 | en_US |
| dc.identifier.uri | https://hdl.handle.net/1805/15688 | |
| dc.language.iso | en | en_US |
| dc.publisher | ACS | en_US |
| dc.relation.isversionof | 10.1021/jacs.7b05571 | en_US |
| dc.relation.journal | Journal of the American Chemical Society | en_US |
| dc.rights | Publisher Policy | en_US |
| dc.source | Author | en_US |
| dc.subject | mass spectrometry | en_US |
| dc.subject | 3D printed cartridge | en_US |
| dc.subject | targeted protein detection | en_US |
| dc.title | Targeted Protein Detection using an All-In-One Mass Spectrometry Cartridge | en_US |
| dc.type | Article | en_US |