Targeted Protein Detection using an All-In-One Mass Spectrometry Cartridge
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2017-07
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English
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Abstract
We developed a simple 3D printed cartridge for mass spectrometry (MS) targeted detection of plasma proteins, including post-translational modifications (PTMs). The cartridge uses an integrated antibody enrichment column to preconcentrate the protein target as well as a novel built-in substrate to ionize the protein targets for MS detection. We show several examples of using this cartridge to perform rapid detection of clinically significant proteoforms from plasma samples.
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Zhang, C., Glaros, T., & Manicke, N. E. (2017). Targeted Protein Detection Using an All-in-One Mass Spectrometry Cartridge. Journal of the American Chemical Society, 139(32), 10996–10999. https://doi.org/10.1021/jacs.7b05571
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Journal of the American Chemical Society
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