Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss
Date
2022
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English
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Abstract
This work rests on our non-viral tissue nanotransfection (TNT) platform to deliver MyoD (TNT) to injured tissue in vivo. TNT was performed on skin and successfully induced expression of myogenic factors. TNT was then used as a therapy 7 days following volumetric muscle loss (VML) of rat tibialis anterior and rescued muscle function. TNT is promising as VML intervention.
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Clark, A., Ghatak, S., Guda, P. R., El Masry, M. S., Xuan, Y., Sato, A. Y., Bellido, T., & Sen, C. K. (2022). Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss. Npj Regenerative Medicine, 7(1), Article 1. https://doi.org/10.1038/s41536-022-00259-y
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36266362
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NPJ Regenerative Medicine
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Article
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Final published version