Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure
| dc.contributor.author | Tonetti, D.A. | |
| dc.contributor.author | Morrow, M. | |
| dc.contributor.author | Kidwai, N. | |
| dc.contributor.author | Gupta, A. | |
| dc.contributor.author | Badve, Sunil | |
| dc.contributor.department | Pathology and Laboratory Medicine, School of Medicine | en_US |
| dc.date.accessioned | 2021-02-04T15:29:48Z | |
| dc.date.available | 2021-02-04T15:29:48Z | |
| dc.date.issued | 2003-04-29 | |
| dc.description.abstract | We previously reported that stable transfection of protein kinase C alpha (PKCα) into T47D human breast cancer cells results in tamoxifen (TAM)-resistant tumour growth. Relevance of PKCα expression in clinical specimens was determined by comparing PKCα expression in tumours from patients exhibiting disease recurrence with patients remaining disease-free following TAM treatment. Our results suggest that PKCα expression may predict TAM treatment failure. | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.identifier.citation | Tonetti, D., Morrow, M., Kidwai, N. et al. Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure. Br J Cancer 88, 1400–1402 (2003). https://doi.org/10.1038/sj.bjc.6600923 | en_US |
| dc.identifier.uri | https://hdl.handle.net/1805/25144 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Cancer Research UK | en_US |
| dc.relation.isversionof | 10.1038/sj.bjc.6600923 | en_US |
| dc.relation.journal | British Journal of Cancer | en_US |
| dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
| dc.source | Publisher | en_US |
| dc.subject | breast cancer | en_US |
| dc.subject | tamoxifen resistance | en_US |
| dc.subject | protein kinase C alpha | en_US |
| dc.title | Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure | en_US |
| dc.type | Article | en_US |