Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure
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Date
2003-04-29
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American English
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Cancer Research UK
Abstract
We previously reported that stable transfection of protein kinase C alpha (PKCα) into T47D human breast cancer cells results in tamoxifen (TAM)-resistant tumour growth. Relevance of PKCα expression in clinical specimens was determined by comparing PKCα expression in tumours from patients exhibiting disease recurrence with patients remaining disease-free following TAM treatment. Our results suggest that PKCα expression may predict TAM treatment failure.
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Tonetti, D., Morrow, M., Kidwai, N. et al. Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure. Br J Cancer 88, 1400–1402 (2003). https://doi.org/10.1038/sj.bjc.6600923
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British Journal of Cancer
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