Multi-focal Clostridioides (Clostridium) difficile osteomyelitis in a patient with sickle cell anemia: case presentation and literature review
dc.contributor.author | Al-Tawfiq, Jaffar A. | |
dc.contributor.author | Babiker, Mohammad | |
dc.contributor.department | Medicine, School of Medicine | en_US |
dc.date.accessioned | 2020-01-23T21:07:32Z | |
dc.date.available | 2020-01-23T21:07:32Z | |
dc.date.issued | 2020-01 | |
dc.description.abstract | Clostridioides (Clostridium) difficile infection manifests as intestinal infections, namely pseudomembranous colitis. The occurrence of extra-intestinal disease is thought to be rare with a rate of 1.08% of 2034 isolates of C. difficile and an incidence of 4/100,000 admissions. C. difficile had been rarely associated with osteomyelitis. Here, we report the occurrence of C. difficile osteomyelitiin a patient with sickle cell disease. The patient had multiple surgeries and a prolonged antimicrobial therapy to achieve a cure. The patient had C. difficile infection of native bone and of a prosthetic joint. The patient received prolonged therapy with amoxicillin-clavulanic acid and metronidazole and she remained free of C. difficile infection for 3 years off antibiotics. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Al-Tawfiq, J. A., & Babiker, M. M. (2020). Multi-focal Clostridioides (Clostridium) difficile osteomyelitis in a patient with sickle cell anemia: Case presentation and literature review. Diagnostic Microbiology and Infectious Disease, 96(1), 114915. https://doi.org/10.1016/j.diagmicrobio.2019.114915 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/21900 | |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.diagmicrobio.2019.114915 | en_US |
dc.relation.journal | Diagnostic Microbiology and Infectious Disease | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | Publisher | en_US |
dc.subject | Clostridium difficile | en_US |
dc.subject | osteomyelitis | en_US |
dc.subject | sickle cell anemia | en_US |
dc.title | Multi-focal Clostridioides (Clostridium) difficile osteomyelitis in a patient with sickle cell anemia: case presentation and literature review | en_US |
dc.type | Article | en_US |