False-negative Histoplasma antigen in acute pulmonary histoplasmosis: the value of urinary concentration by ultrafiltration and heat denaturation of serum proteins in detection of Histoplasma antigen
Date
2009-05
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American English
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Lippincott, Williams & Wilkins
Abstract
We report an infant with localized pulmonary histoplasmosis in whom Histoplasma antibody assays, quantitative Histoplasma urine and serum antigen concentrations, and histopathologic findings of a mediastinal mass were nondiagnostic. A provisional diagnosis of histoplasmosis was established by using laboratory methods that increase the sensitivity of the antigen assay using ultrafiltration of urine and ethylenediaminetetraacetic acid/heat denaturation of serum proteins.
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Srinivasan, A., Kleiman, M. B., Debelenko, L., Stokes, D. C., De Vincenzo, J., & Wheat, J. L. (2009). False-negative Histoplasma antigen in acute pulmonary histoplasmosis: the value of urinary concentration by ultrafiltration and heat denaturation of serum proteins in detection of Histoplasma antigen. The Pediatric Infectious Disease Journal, 28(5), 447–449. https://doi.org/10.1097/INF.0b013e318193ecc1
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0891-3668
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The Pediatric infectious disease journal
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PMC
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Article
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Author's manuscript