A Single Dose of Dietary Nitrate Increases Maximal Knee Extensor Angular Velocity and Power in Healthy Older Men and Women

dc.contributor.authorCoggan, Andrew R
dc.contributor.authorHoffman, Richard L
dc.contributor.authorGray, Derrick A
dc.contributor.authorMoorthi, Ranjani N
dc.contributor.authorThomas, Deepak P
dc.contributor.authorLeibowitz, Joshua L
dc.contributor.authorThies, Dakkota
dc.contributor.authorPeterson, Linda R
dc.contributor.departmentKinesiology, School of Physical Education and Tourism Managementen_US
dc.date.accessioned2021-01-21T16:31:54Z
dc.date.available2021-01-21T16:31:54Z
dc.date.issued2019-07-22
dc.description.abstractBackground Aging results in reductions in maximal muscular strength, speed, and power, which often lead to functional limitations highly predictive of disability, institutionalization, and mortality in elderly adults. This may be partially due to reduced nitric oxide (NO) bioavailability. We, therefore, hypothesized that dietary nitrate (NO3−), a source of NO via the NO3− → nitrite (NO2−) → NO enterosalivary pathway, could increase muscle contractile function in older subjects. Methods Twelve healthy older (age 71 ± 5 years) men and women were studied using a randomized, double-blind, placebo-controlled, crossover design. After fasting overnight, subjects were tested 2 hours after ingesting beetroot juice containing or devoid of 13.4 ± 1.6 mmol NO3−. Plasma NO3− and NO2− and breath NO were measured periodically, and muscle function was determined using isokinetic dynamometry. Results NO3− ingestion increased (p < .001) plasma NO3−, plasma NO2−, and breath NO by 1,051% ± 433%, 138% ± 149%, and 111% ± 115%, respectively. Maximal velocity of knee extension increased (p < .01) by 10.9% ± 12.1%. Maximal knee extensor power increased (p < .05) by 4.4% ± 7.8%. Conclusions Acute dietary NO3− intake improves maximal knee extensor angular velocity and power in older individuals. These findings may have important implications for this population, in whom diminished muscle function can lead to functional limitations, dependence, and even premature death.en_US
dc.identifier.citationCoggan, A. R., Hoffman, R. L., Gray, D. A., Moorthi, R. N., Thomas, D. P., Leibowitz, J. L., Thies, D., & Peterson, L. R. (2020). A Single Dose of Dietary Nitrate Increases Maximal Knee Extensor Angular Velocity and Power in Healthy Older Men and Women. The Journals of Gerontology: Series A, 75(6), 1154–1160. https://doi.org/10.1093/gerona/glz156en_US
dc.identifier.issn1079-5006en_US
dc.identifier.urihttps://hdl.handle.net/1805/24905
dc.language.isoen_USen_US
dc.publisherOxforden_US
dc.relation.isversionof10.1093/gerona/glz156en_US
dc.relation.journalThe Journals of Gerontology: Series Aen_US
dc.sourcePMCen_US
dc.subjectNitric oxideen_US
dc.subjectNitriteen_US
dc.subjectIsokinetic dynamometryen_US
dc.subjectBlood pressureen_US
dc.titleA Single Dose of Dietary Nitrate Increases Maximal Knee Extensor Angular Velocity and Power in Healthy Older Men and Womenen_US
dc.typeArticleen_US
ul.alternative.fulltexthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243590/en_US
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