Oxidation of Hydrogen Sulfide to Polysulfide and Thiosulfate by a Carbon Nanozyme: Therapeutic Implications with an Emphasis on Down Syndrome

dc.contributor.authorDerry, Paul J.
dc.contributor.authorLiopo, Anton V.
dc.contributor.authorMouli, Karthik
dc.contributor.authorMcHugh, Emily A.
dc.contributor.authorVo, Anh T. T.
dc.contributor.authorMcKelvey, Ann
dc.contributor.authorSuv, Larry J.
dc.contributor.authorWu, Gang
dc.contributor.authorGao, Yan
dc.contributor.authorOlson, Kenneth R.
dc.contributor.authorTour, James M.
dc.contributor.authorKent, Thomas A.
dc.contributor.departmentCellular and Integrative Physiology, School of Medicine
dc.date.accessioned2025-04-23T08:40:16Z
dc.date.available2025-04-23T08:40:16Z
dc.date.issued2024
dc.description.abstractHydrogen sulfide (H2 S) is a noxious, potentially poisonous, but necessary gas produced from sulfur metabolism in humans. In Down Syndrome (DS), the production of H2 S is elevated and associated with degraded mitochondrial function. Therefore, removing H2 S from the body as a stable oxide could be an approach to reducing the deleterious effects of H2 S in DS. In this report we describe the catalytic oxidation of hydrogen sulfide (H2 S) to polysulfides (HS2+n - ) and thiosulfate (S2 O3 2- ) by poly(ethylene glycol) hydrophilic carbon clusters (PEG-HCCs) and poly(ethylene glycol) oxidized activated charcoal (PEG-OACs), examples of oxidized carbon nanozymes (OCNs). We show that OCNs oxidize H2 S to polysulfides and S2 O3 2- in a dose-dependent manner. The reaction is dependent on O2 and the presence of quinone groups on the OCNs. In DS donor lymphocytes we found that OCNs increased polysulfide production, proliferation, and afforded protection against additional toxic levels of H2 S compared to untreated DS lymphocytes. Finally, in Dp16 and Ts65DN murine models of DS, we found that OCNs restored osteoclast differentiation. This new action suggests potential facile translation into the clinic for conditions involving excess H2 S exemplified by DS.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationDerry PJ, Liopo AV, Mouli K, et al. Oxidation of Hydrogen Sulfide to Polysulfide and Thiosulfate by a Carbon Nanozyme: Therapeutic Implications with an Emphasis on Down Syndrome. Adv Mater. 2024;36(10):e2211241. doi:10.1002/adma.202211241
dc.identifier.urihttps://hdl.handle.net/1805/47366
dc.language.isoen_US
dc.publisherWiley
dc.relation.isversionof10.1002/adma.202211241
dc.relation.journalAdvanced Materials
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectCatalysis
dc.subjectHydrogen sulfide
dc.subjectNanozyme
dc.subjectTranslational research
dc.titleOxidation of Hydrogen Sulfide to Polysulfide and Thiosulfate by a Carbon Nanozyme: Therapeutic Implications with an Emphasis on Down Syndrome
dc.typeArticle
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