Limited Approaches for Genomic Studies in Rapid Postmortem Tissue Collection

Abstract

Rapid postmortem tissue collection has been shown to have increasing use for molecular and genetic profiling. Although research on human tissue has been conducted for many years, modern molecular assays have significantly higher sensitivity and specificity than those used in the past. Higher grade tissue specimens are now required for the extraction of macromolecules as a result of this. In fact, these studies have paved the way for multiple postmortem tissue collection studies such as COVID-19, brain, skin, and small cell lung cancer. Best practices for tissue collection have also been developed by a number of professional organizations, including the National Institutes of Health Office of Biorepositories and the International Society of Biological and Environmental Repositories (ISBER). These guidelines can be used to establish procedures for tissue collection.