Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation

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dc.contributor.authorBatra, Sandeep
dc.contributor.authorMartin, Stephen C.
dc.contributor.authorNassiri, Mehdi
dc.contributor.authorQureshi, Amna
dc.contributor.authorMarkel, Troy A.
dc.contributor.departmentDepartment of Pediatrics, IU School of Medicineen_US
dc.date.accessioned2017-05-19T17:28:39Z
dc.date.available2017-05-19T17:28:39Z
dc.date.issued2016
dc.description.abstractHistiocytic sarcoma (HS) rarely involves extranodal sites, such as the spleen. We report a unique pediatric case of massive splenomegaly and refractory Coombs negative hemolytic anemia (CNHA) secondary to HS. The CNHA resolved completely after an emergent splenectomy. Next generation sequencing (NGS) revealed novel ASXL1, PTPN11, KIT, and TP53 mutations, unmasking a clonal heterogeneity within the same neoplasm.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationBatra, S., Martin, S. C., Nassiri, M., Qureshi, A., & Markel, T. A. (2016). Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation. Case Reports in Oncological Medicine, 2016, 3179147. http://doi.org/10.1155/2016/3179147en_US
dc.identifier.issn2090-6706en_US
dc.identifier.urihttps://hdl.handle.net/1805/12633
dc.language.isoen_USen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.isversionof10.1155/2016/3179147en_US
dc.relation.journalCase Reports in Oncological Medicineen_US
dc.rightsAttribution 3.0 United States
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/
dc.sourcePMCen_US
dc.subjectHistiocytic Sarcomaen_US
dc.subjectAnemia, Hemolyticen_US
dc.subjectSplenectomyen_US
dc.subjectAdolescentsen_US
dc.titleHistiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentationen_US
dc.typeArticleen_US
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