Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation
Date
2016
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American English
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Hindawi Publishing Corporation
Abstract
Histiocytic sarcoma (HS) rarely involves extranodal sites, such as the spleen. We report a unique pediatric case of massive splenomegaly and refractory Coombs negative hemolytic anemia (CNHA) secondary to HS. The CNHA resolved completely after an emergent splenectomy. Next generation sequencing (NGS) revealed novel ASXL1, PTPN11, KIT, and TP53 mutations, unmasking a clonal heterogeneity within the same neoplasm.
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Cite As
Batra, S., Martin, S. C., Nassiri, M., Qureshi, A., & Markel, T. A. (2016). Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation. Case Reports in Oncological Medicine, 2016, 3179147. http://doi.org/10.1155/2016/3179147
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2090-6706
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Case Reports in Oncological Medicine
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PMC
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Article
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Final published version