Per2-Mediated Vascular Dysfunction Is Caused by the Upregulation of the Connective Tissue Growth Factor (CTGF).

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dc.contributor.authorJadhav, Vaishnavi
dc.contributor.authorLuo, Qianyi
dc.contributor.authorM. Dominguez, James
dc.contributor.authorAl-Sabah, Jude
dc.contributor.authorChaqour, Brahim
dc.contributor.authorGrant, Maria B.
dc.contributor.authorBhatwadekar, Ashay D.
dc.contributor.departmentDepartment of Ophthalmology, IU School of Medicineen_US
dc.date.accessioned2016-12-21T20:26:04Z
dc.date.available2016-12-21T20:26:04Z
dc.date.issued2016
dc.description.abstractPeriod 2-mutant mice (Per2m/m), which possess a circadian dysfunction, recapitulate the retinal vascular phenotype similar to diabetic retinopathy (DR). The vascular dysfunction in Per2m/m is associated with an increase in connective tissue growth factor (CTGF/CCN2). At the molecular level, CTGF gene expression is dependent on the canonical Wnt/β-catenin pathway. The nuclear binding of β-catenin to a transcription factor, lymphoid enhancer binding protein (Lef)/en_US
dc.eprint.versionPublished versionen_US
dc.identifier.citationJadhav, V., Luo, Q., 2nd, J. M. D., Al-Sabah, J., Chaqour, B., Grant, M. B., & Bhatwadekar, A. D. (2016). Per2-Mediated Vascular Dysfunction Is Caused by the Upregulation of the Connective Tissue Growth Factor (CTGF). PLOS ONE, 11(9), e0163367. https://doi.org/10.1371/journal.pone.0163367en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttps://hdl.handle.net/1805/11684
dc.language.isoen_USen_US
dc.publisherPLOSen_US
dc.relation.isversionof10.1371/journal.pone.0163367en_US
dc.relation.journalPLoS ONEen_US
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePublisheren_US
dc.subjectDiabetesen_US
dc.subjectRetinal vesselsen_US
dc.subjectProtein expressionen_US
dc.titlePer2-Mediated Vascular Dysfunction Is Caused by the Upregulation of the Connective Tissue Growth Factor (CTGF).en_US
dc.typeArticleen_US
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