Per2-Mediated Vascular Dysfunction Is Caused by the Upregulation of the Connective Tissue Growth Factor (CTGF).
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Date
2016
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American English
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PLOS
Abstract
Period 2-mutant mice (Per2m/m), which possess a circadian dysfunction, recapitulate the retinal vascular phenotype similar to diabetic retinopathy (DR). The vascular dysfunction in Per2m/m is associated with an increase in connective tissue growth factor (CTGF/CCN2). At the molecular level, CTGF gene expression is dependent on the canonical Wnt/β-catenin pathway. The nuclear binding of β-catenin to a transcription factor, lymphoid enhancer binding protein (Lef)/
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Jadhav, V., Luo, Q., 2nd, J. M. D., Al-Sabah, J., Chaqour, B., Grant, M. B., & Bhatwadekar, A. D. (2016). Per2-Mediated Vascular Dysfunction Is Caused by the Upregulation of the Connective Tissue Growth Factor (CTGF). PLOS ONE, 11(9), e0163367. https://doi.org/10.1371/journal.pone.0163367
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1932-6203
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PLoS ONE
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Article
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