Molecular Requirement for Sterols in Herpes Simplex Virus Entry and Infectivity

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dc.contributor.authorWudiri, George A.
dc.contributor.authorPritchard, Suzanne M.
dc.contributor.authorLi, Hong
dc.contributor.authorLiu, Jin
dc.contributor.authorAguilar, Hector C.
dc.contributor.authorGilk, Stacey D.
dc.contributor.authorNicola, Anthony V.
dc.contributor.departmentDepartment of Microbiology & Immunology, IU School of Medicineen_US
dc.date.accessioned2016-03-22T18:12:21Z
dc.date.available2016-03-22T18:12:21Z
dc.date.issued2014-12
dc.description.abstractHerpes simplex virus 1 (HSV-1) required cholesterol or desmosterol for virion-induced membrane fusion. HSV successfully entered DHCR24−/− cells, which lack a desmosterol-to-cholesterol conversion enzyme, indicating that entry can occur independently of cholesterol. Depletion of desmosterol from these cells resulted in diminished HSV-1 entry, suggesting a general sterol requirement for HSV-1 entry and that desmosterol can operate in virus entry. Cholesterol functioned more effectively than desmosterol, suggesting that the hydrocarbon tail of cholesterol influences viral entry.en_US
dc.identifier.citationWudiri, G. A., Pritchard, S. M., Li, H., Liu, J., Aguilar, H. C., Gilk, S. D., & Nicola, A. V. (2014). Molecular Requirement for Sterols in Herpes Simplex Virus Entry and Infectivity. Journal of Virology, 88(23), 13918–13922. http://doi.org/10.1128/JVI.01615-14en_US
dc.identifier.urihttps://hdl.handle.net/1805/8966
dc.language.isoen_USen_US
dc.publisherAmerican Society for Microbiology (ASM)en_US
dc.relation.isversionof10.1128/JVI.01615-14en_US
dc.relation.journalJournal of Virologyen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectAnimalsen_US
dc.subjectCell Lineen_US
dc.subjectCholesterolen_US
dc.subjectDesmosterolen_US
dc.subjectHerpesvirus 1, Humanen_US
dc.subjectVirus Internalizationen_US
dc.titleMolecular Requirement for Sterols in Herpes Simplex Virus Entry and Infectivityen_US
dc.typeArticleen_US
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