Molecular Requirement for Sterols in Herpes Simplex Virus Entry and Infectivity
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Date
2014-12
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American English
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American Society for Microbiology (ASM)
Abstract
Herpes simplex virus 1 (HSV-1) required cholesterol or desmosterol for virion-induced membrane fusion. HSV successfully entered DHCR24−/− cells, which lack a desmosterol-to-cholesterol conversion enzyme, indicating that entry can occur independently of cholesterol. Depletion of desmosterol from these cells resulted in diminished HSV-1 entry, suggesting a general sterol requirement for HSV-1 entry and that desmosterol can operate in virus entry. Cholesterol functioned more effectively than desmosterol, suggesting that the hydrocarbon tail of cholesterol influences viral entry.
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Wudiri, G. A., Pritchard, S. M., Li, H., Liu, J., Aguilar, H. C., Gilk, S. D., & Nicola, A. V. (2014). Molecular Requirement for Sterols in Herpes Simplex Virus Entry and Infectivity. Journal of Virology, 88(23), 13918–13922. http://doi.org/10.1128/JVI.01615-14
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Journal of Virology
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PMC
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Article