Five-Year Longitudinal Assessment (2008 to 2012) of E-101 Solution Activity against Clinical Target and Antimicrobial-Resistant Pathogens

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dc.contributor.authorDenys, Gerald A.
dc.contributor.authorPillar, Chris M.
dc.contributor.authorSahm, Daniel F.
dc.contributor.authorO'Hanley, Peter
dc.contributor.authorStephens, Jackson T. Jr
dc.contributor.departmentDepartment of Pathology & Laboratory Medicine, IU School of Medicineen_US
dc.date.accessioned2016-03-21T22:11:31Z
dc.date.available2016-03-21T22:11:31Z
dc.date.issued2014-08
dc.description.abstractThis study summarizes the topical E-101 solution susceptibility testing results for 760 Gram-positive and Gram-negative target pathogens collected from 75 U.S. sites between 2008 and 2012 and 103 ESKAPE pathogens. E-101 solution maintained potent activity against all bacterial species studied for each year tested, with MICs ranging from <0.008 to 0.25 μg porcine myeloperoxidase (pMPO)/ml. These results confirm that E-101 solution retains its potent broad-spectrum activity against U.S. clinical isolates and organisms with challenging resistance phenotypes.en_US
dc.identifier.citationDenys, G. A., Pillar, C. M., Sahm, D. F., O’Hanley, P., & Stephens, J. T. (2014). Five-Year Longitudinal Assessment (2008 to 2012) of E-101 Solution Activity against Clinical Target and Antimicrobial-Resistant Pathogens. Antimicrobial Agents and Chemotherapy, 58(8), 4911–4914. http://doi.org/10.1128/AAC.03020-14en_US
dc.identifier.urihttps://hdl.handle.net/1805/8961
dc.language.isoen_USen_US
dc.publisherAmerican Society for Microbiology (ASM)en_US
dc.relation.isversionof10.1128/AAC.03020-14en_US
dc.relation.journalAntimicrobial Agents and Chemotherapyen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectAnti-Infective Agentsen_US
dc.subjectDrug Resistance, Multiple, Bacterialen_US
dc.subjectGlucose Oxidaseen_US
dc.subjectGram-Negative Bacteriaen_US
dc.subjectGram-Negative Bacterial Infectionsen_US
dc.subjectHumansen_US
dc.subjectHydrogen Peroxideen_US
dc.subjectHypochlorous Aciden_US
dc.subjectLongitudinal Studiesen_US
dc.subjectMicrobial Sensitivity Testsen_US
dc.subjectOxidation-Reductionen_US
dc.subjectPeroxidaseen_US
dc.subjectPharmaceutical Solutionsen_US
dc.subjectSinglet Oxygenen_US
dc.titleFive-Year Longitudinal Assessment (2008 to 2012) of E-101 Solution Activity against Clinical Target and Antimicrobial-Resistant Pathogensen_US
dc.typeArticleen_US
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