Five-Year Longitudinal Assessment (2008 to 2012) of E-101 Solution Activity against Clinical Target and Antimicrobial-Resistant Pathogens
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2014-08
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American English
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American Society for Microbiology (ASM)
Abstract
This study summarizes the topical E-101 solution susceptibility testing results for 760 Gram-positive and Gram-negative target pathogens collected from 75 U.S. sites between 2008 and 2012 and 103 ESKAPE pathogens. E-101 solution maintained potent activity against all bacterial species studied for each year tested, with MICs ranging from <0.008 to 0.25 μg porcine myeloperoxidase (pMPO)/ml. These results confirm that E-101 solution retains its potent broad-spectrum activity against U.S. clinical isolates and organisms with challenging resistance phenotypes.
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Anti-Infective Agents, Drug Resistance, Multiple, Bacterial, Glucose Oxidase, Gram-Negative Bacteria, Gram-Negative Bacterial Infections, Humans, Hydrogen Peroxide, Hypochlorous Acid, Longitudinal Studies, Microbial Sensitivity Tests, Oxidation-Reduction, Peroxidase, Pharmaceutical Solutions, Singlet Oxygen
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Cite As
Denys, G. A., Pillar, C. M., Sahm, D. F., O’Hanley, P., & Stephens, J. T. (2014). Five-Year Longitudinal Assessment (2008 to 2012) of E-101 Solution Activity against Clinical Target and Antimicrobial-Resistant Pathogens. Antimicrobial Agents and Chemotherapy, 58(8), 4911–4914. http://doi.org/10.1128/AAC.03020-14
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Antimicrobial Agents and Chemotherapy
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PMC
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Article