Impaired compensation to femoral artery ligation in diet-induced obese mice is primarily mediated via suppression of collateral growth by Nox2 and p47phox.

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dc.contributor.authorDiStasi, Matthew R.
dc.contributor.authorMund, Julie A.
dc.contributor.authorBohlen, H. Glenn
dc.contributor.authorMiller, Steven J.
dc.contributor.authorIngram, David A.
dc.contributor.authorDalsing, Michael C.
dc.contributor.authorUnthank, Joseph L.
dc.contributor.departmentDepartment of Cellular and Integrative Physiology, IU School of Medicineen_US
dc.date.accessioned2016-12-19T22:05:58Z
dc.date.available2016-12-19T22:05:58Z
dc.date.issued2015-10
dc.description.abstractNovel observations in this report include the demonstration of collateral resistance as the primary limitation of hindlimb perfusion, elevated NADPH oxidase (Nox) expression in peripheral arteries, unimpaired monocyte mobilization and demargination, and reversal of suppressed principle collateral growth by Nox2 ablation/inhibition in a diet-induced obese mouse model of arterial occlusion.en_US
dc.eprint.versionPublished versionen_US
dc.identifier.citationDiStasi, M. R., Mund, J. A., Bohlen, H. G., Miller, S. J., Ingram, D. A., Dalsing, M. C., & Unthank, J. L. (2015). Impaired compensation to femoral artery ligation in diet-induced obese mice is primarily mediated via suppression of collateral growth by Nox2 and p47phox. American Journal of Physiology. Heart and Circulatory Physiology, 309(7), H1207-1217. https://doi.org/10.1152/ajpheart.00180.2015en_US
dc.identifier.issn0363-6135 1522-1539en_US
dc.identifier.urihttps://hdl.handle.net/1805/11665
dc.language.isoen_USen_US
dc.publisherAPSen_US
dc.relation.isversionof10.1152/ajpheart.00180.2015en_US
dc.relation.journalAmerican Journal of Physiology - Heart and Circulatory Physiologyen_US
dc.rightsPublisher's Policyen_US
dc.sourcePMCen_US
dc.subjectNADPH oxidaseen_US
dc.subjectNox2en_US
dc.subjectarteriogenesisen_US
dc.subjectcollateral resistanceen_US
dc.subjectvascular resistanceen_US
dc.titleImpaired compensation to femoral artery ligation in diet-induced obese mice is primarily mediated via suppression of collateral growth by Nox2 and p47phox.en_US
dc.typeArticleen_US
ul.alternative.fulltexthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666923/en_US
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