Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival

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dc.contributor.authorVillagomez, Fabian R.
dc.contributor.authorLang, Julie
dc.contributor.authorNunez-Avellaneda, Daniel
dc.contributor.authorBehbakht, Kian
dc.contributor.authorDimmick, Hannah L.
dc.contributor.authorWebb, Patricia G.
dc.contributor.authorNephew, Kenneth P.
dc.contributor.authorNeville, Margaret
dc.contributor.authorWoodruff, Elizabeth R.
dc.contributor.authorBitler, Benjamin G.
dc.contributor.departmentAnatomy, Cell Biology and Physiology, School of Medicine
dc.date.accessioned2025-02-28T17:04:53Z
dc.date.available2025-02-28T17:04:53Z
dc.date.issued2025
dc.description.abstractHigh-grade serous ovarian carcinoma is marked by chromosomal instability, which can serve to promote disease progression and allow cancer to evade therapeutic insults. The report highlights the role of claudin-4 in regulating genomic instability and proposes a novel therapeutic approach to exploit claudin-4-mediated regulation.
dc.eprint.versionFinal published version
dc.identifier.citationVillagomez FR, Lang J, Nunez-Avellaneda D, et al. Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival. Cancer Res Commun. 2025;5(1):39-53. doi:10.1158/2767-9764.CRC-24-0558
dc.identifier.urihttps://hdl.handle.net/1805/46136
dc.language.isoen_US
dc.publisherAmerican Association for Cancer Research
dc.relation.isversionof10.1158/2767-9764.CRC-24-0558
dc.relation.journalCancer Research Communications
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePMC
dc.subjectCell cycle
dc.subjectClaudin-4
dc.subjectGenomic instability
dc.subjectOvarian neoplasms
dc.titleClaudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
dc.typeArticle
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