Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival
Date
2025
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American English
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American Association for Cancer Research
Abstract
High-grade serous ovarian carcinoma is marked by chromosomal instability, which can serve to promote disease progression and allow cancer to evade therapeutic insults. The report highlights the role of claudin-4 in regulating genomic instability and proposes a novel therapeutic approach to exploit claudin-4-mediated regulation.
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Villagomez FR, Lang J, Nunez-Avellaneda D, et al. Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival. Cancer Res Commun. 2025;5(1):39-53. doi:10.1158/2767-9764.CRC-24-0558
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Cancer Research Communications
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PMC
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Article
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Final published version