Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight.

Simple item page
dc.contributor.authorQiu, Bin
dc.contributor.authorBell, Richard L.
dc.contributor.authorCao, Yong
dc.contributor.authorZhang, Lingling
dc.contributor.authorStewart, Robert B.
dc.contributor.authorGraves, Tamara
dc.contributor.authorLumeng, Lawrence
dc.contributor.authorYong, Weidong
dc.contributor.authorLiang, Tiebing
dc.contributor.departmentDepartment of Psychiatry, IU School of Medicineen_US
dc.date.accessioned2016-12-08T23:30:42Z
dc.date.available2016-12-08T23:30:42Z
dc.date.issued2016-07-20
dc.description.abstractNeuropeptide Y (NPY) is widely expressed in the central nervous system and influences many physiological processes. It is located within the rat quantitative trait locus (QTL) for alcohol preference on chromosome 4. Alcohol-nonpreferring (NP) rats consume very little alcohol, but have significantly higher NPY expression in the brain than alcohol-preferring (P) rats. We capitalized on this phenotypic difference by creating an Npy knockout (KO) rat using the inbred NP background to evaluate NPY effects on alcohol consumption. Zinc finger nuclease (ZNF) technology was applied, resulting in aen_US
dc.eprint.versionAccepted Manuscripten_US
dc.identifier.citationQiu, B., Bell, R. L., Cao, Y., Zhang, L., Stewart, R. B., Graves, T., … Liang, T. (2016). Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight. Journal of Genetics and Genomics = Yi Chuan Xue Bao, 43(7), 421–430. https://doi.org/10.1016/j.jgg.2016.04.010
dc.identifier.issn1673-8527en_US
dc.identifier.urihttps://hdl.handle.net/1805/11583
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.jgg.2016.04.010en_US
dc.relation.journalJournal of genetics and genomics = Yi chuan xue baoen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectAlcohol drinking behavioren_US
dc.subjectBDNFen_US
dc.subjectCRH and receptorsen_US
dc.subjectKnockout raten_US
dc.subjectMelanocortin and receptorsen_US
dc.subjectNPY and receptorsen_US
dc.titleNpy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
nihms-818373.pdf
Size:
2.05 MB
Format:
Adobe Portable Document Format
Download
Collections
Open Access Policy Articles
Department of Psychiatry Works