Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight.
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Date
2016-07-20
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American English
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Elsevier
Abstract
Neuropeptide Y (NPY) is widely expressed in the central nervous system and influences many physiological processes. It is located within the rat quantitative trait locus (QTL) for alcohol preference on chromosome 4. Alcohol-nonpreferring (NP) rats consume very little alcohol, but have significantly higher NPY expression in the brain than alcohol-preferring (P) rats. We capitalized on this phenotypic difference by creating an Npy knockout (KO) rat using the inbred NP background to evaluate NPY effects on alcohol consumption. Zinc finger nuclease (ZNF) technology was applied, resulting in a
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Qiu, B., Bell, R. L., Cao, Y., Zhang, L., Stewart, R. B., Graves, T., … Liang, T. (2016). Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight. Journal of Genetics and Genomics = Yi Chuan Xue Bao, 43(7), 421–430. https://doi.org/10.1016/j.jgg.2016.04.010
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1673-8527
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Journal of genetics and genomics = Yi chuan xue bao
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PMC
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Article
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Accepted Manuscript