Open Access Policy Articles

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https://hdl.handle.net/1805/3272

The IUPUI Faculty Council adopted an open access policy on October 7th, 2014 (available from: https://openaccess.indianapolis.iu.edu/). This policy shows IUPUI's commitment to disseminating the fruits of research and scholarship as widely as possible. Open access policies increase authors’ rights, readership and citation rates for scholarly articles. The opt out provision ensures that all faculty authors have the freedom to publish in the journal of their choice.

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Now showing 1 - 10 of 27462

Deletion of the auxiliary α2δ1 voltage sensitive calcium channel subunit in osteocytes and late-stage osteoblasts impairs femur strength and load-induced bone formation in male mice
(Oxford, 2024) Wright, Christian S.; Lewis, Karl J.; Semon, Katelyn; Yi, Xin; Reyes Fernandez, Perla C.; Rust, Katie; Prideaux, Matthew; Schneider, Artur; Pederson, Molly; Deosthale, Padmini; Plotkin, Lilian I.; Hum, Julia M.; Sankar, Uma; Farach-Carson, Mary C.; Robling, Alexander G.; Thompson, William R.; Health Sciences, School of Health and Human Sciences
Osteocytes sense and respond to mechanical force by controlling the activity of other bone cells. However, the mechanisms by which osteocytes sense mechanical input and transmit biological signals remain unclear. Voltage-sensitive calcium channels (VSCCs) regulate calcium (Ca2+) influx in response to external stimuli. Inhibition or deletion of VSCCs impairs osteogenesis and skeletal responses to mechanical loading. VSCC activity is influenced by its auxiliary subunits, which bind the channel’s α1 pore-forming subunit to alter intracellular Ca2+ concentrations. The α2δ1 auxiliary subunit associates with the pore-forming subunit via a glycosylphosphatidylinositol anchor and regulates the channel’s calcium-gating kinetics. Knockdown of α2δ1 in osteocytes impairs responses to membrane stretch, and global deletion of α2δ1 in mice results in osteopenia and impaired skeletal responses to loading in vivo. Therefore, we hypothesized that the α2δ1 subunit functions as a mechanotransducer, and its deletion in osteocytes would impair skeletal development and load-induced bone formation. Mice (C57BL/6) with LoxP sequences flanking Cacna2d1, the gene encoding α2δ1, were crossed with mice expressing Cre under the control of the Dmp1 promoter (10 kb). Deletion of α2δ1 in osteocytes and late-stage osteoblasts decreased femoral bone quantity (P < .05) by DXA, reduced relative osteoid surface (P < .05), and altered osteoblast and osteocyte regulatory gene expression (P < .01). Cacna2d1f/f, Cre + male mice displayed decreased femoral strength and lower 10-wk cancellous bone in vivo micro-computed tomography measurements at the proximal tibia (P < .01) compared to controls, whereas Cacna2d1f/f, Cre + female mice showed impaired 20-wk cancellous and cortical bone ex vivo micro-computed tomography measurements (P < .05) vs controls. Deletion of α2δ1 in osteocytes and late-stage osteoblasts suppressed load-induced calcium signaling in vivo and decreased anabolic responses to mechanical loading in male mice, demonstrating decreased mechanosensitivity. Collectively, the α2δ1 auxiliary subunit is essential for the regulation of osteoid-formation, femur strength, and load-induced bone formation in male mice.
Case Study: Mapping an E-Voting Based Curriculum to CSEC2017
(ACM, 2023-03) Zheng, Muwei; Swearingen, Nathan; Mills, Steven; Gyurek, Croix; Bishop, Matt; Zou, Xukai; Computer Science, Luddy School of Informatics, Computing, and Engineering
An electronic voting (E-voting) oriented cybersecurity curriculum, proposed by Hostler et al. [4] in 2021, leverages the rich security features of E-voting systems and E-voting process to teach essential concepts of cybersecurity. Existing curricular guidelines describe topics in computer security, but do not instantiate them with examples. This is because their goals are different. In this case study, we map the e-voting curriculum into the CSEC2017 curriculum guidelines, to demonstrate how such a mapping is done. Further, this enables teachers to select the parts of the e-voting curriculum most relevant to their classes, by basing the selection on the relevant CSEC2017 learning objectives. We conclude with a brief discussion on generalizing this mapping to other curricular guidelines.
A Post-Pandemic Reflection of the Changing Role of Contemporary Event Professionals: Implications for Event Professionals and Higher Education
(Taylor & Francis, 2023) Kramer, Savannah Kay; Liu-Lastres, Bingjie; Cecil, Amanda; Shonkwiler, Erica; Tourism, Event & Sport Management, School of Health and Human Sciences
While the event, tourism, and hospitality industry is constantly evolving, COVID-19 vastly shifted the roles, responsibilities, and jobs for event professionals, which caused event management educators to reevaluate their curriculum and course offerings. This study investigated the potential changes COVID-19 has had on event professionals’ skill sets. A mixed-methods research design was adopted, where data were collected from event professionals via focus groups and a national survey. The results highlighted the importance of general business management skillsets (communication, business writing, negotiation) as well as specific event management skills (digital and technology skills). Through a timely reflection on these changes during the pandemic, this study not only highlights the requirements for contemporary event professionals, but also offers implications for higher education institutions regarding how to effectively embrace the new landscape of event management in post-pandemic times.
Cognitive-behavioral and mindfulness-based interventions for distress in patients with advanced cancer: A meta-analysis
(Wiley, 2024-01) Krueger, Ellen; Secinti, Ekin; Stewart, Jesse C.; Rand, Kevin L.; Mosher, Catherine E.; Psychology, School of Science
Objective Various psychosocial interventions have been developed to reduce distress and improve quality of life (QoL) in patients with advanced cancer, many of which are traditional cognitive-behavioral interventions (CBIs) or mindfulness-based interventions (MBIs). The aims of this meta-analysis were to determine and compare the overall effects of traditional CBIs and MBIs on distress and QoL in this population and to explore potential moderators of intervention efficacy. Methods A systematic search was conducted in CINAHL, Embase, PsycINFO, PubMed, and Web of Science. Randomized controlled trials (RCTs) comparing CBIs or MBIs to controls on distress and QoL outcomes were eligible for inclusion. Random effects meta-analyses using standardized baseline to post-intervention mean differences were calculated using Hedges's g. Meta-regressions were used to compare intervention effects and examine potential moderators. Results Across 37 RCTs (21 CBIs, 14 MBIs, 2 combination therapies), there was a small decrease in distress (Hedges's g = 0.21) and a minimal improvement in QoL (Hedges's g = 0.15). Traditional CBIs and MBIs did not differ in effect sizes. Heterogeneity was significant across distress effect sizes but not across QoL effects. Interventions delivered to individuals (vs. dyads/group) had larger effects on QoL. No moderators of intervention effects on distress were found. Conclusions Findings suggest traditional CBIs and MBIs produce small reductions in distress compared to controls in patients with advanced cancer, although effects on QoL appear minimal. Given limitations in the number of studies and their quality, rigorous trials are needed to directly compare the impact of traditional CBIs and MBIs in this population.
Accelerated denture base festooning using a free 3D modeling computer program: A dental technique
(Elsevier, 2024-05) Azpiazu-Flores, Francisco X.; Morton, Dean; Lin, Wei-Shao; Prosthodontics, School of Dentistry
Denture bases should be contoured to recreate the natural contours of the tissues being replaced to ensure optimum phonetics, esthetics, and function.1 Several suggestions have been made regarding the desired shape and contours of the artificial root eminences, denture base extension contours, and surface characterization of the denture base.2–4 Traditionally, achieving these contours has been a time-consuming process done manually during the waxing stage of denture fabrication and requiring significant skill and artistry.2
Building collaboration using the community collaboration initiative model: A case study of Muslim-led nonprofits
(Taylor & Francis, 2023) Siddiqui, Shariq; Wasif, Rafeel; Samad, Abdul; Lilly Family School of Philanthropy
This case study examines three nonprofit leaders’ (Shariq Siddiqui, Roohi Younus and Dilnaz Waraich) attempt to bring together Muslim nonprofit leaders and help them build meaningful collaborations. They kickstarted the Community Collaboration Initiative (CCI), an initiative that uses third-party facilitation to build collaboration among Muslim nonprofit organizations and to educate foundations and donors about the challenges Muslim organizations face in the United States. It serves as an educational resource to examine (1) the collaboration process, (2) trust-building during collaboration, and (3) the challenges of building collaboration. This case study also provides a resource needed to make Muslim-American organizations more visible in nonprofit and public affairs courses, as well as introduce culturally competent funding for nonprofit organizations that is relevant to students planning to work in foundations and related areas.
Adolescent Medicine Fellowship Milestones 2.0: An Overview of Updates
(Elsevier, 2023-07) Sherwin, Nomi; Gómez Rincón, Marianela; Paul, Amy; Ahmed, Saira; Pediatrics, School of Medicine
ChatGPT: Implications for Faculty, Students, and Patients
(Wolters Kluwer, 2023-05) Shay, Amy; School of Nursing
Social Networks and Charitable Giving: Trusting, Doing, Asking, and Alter Primacy
(SAGE, 2018-04-01) Herzog, Patricia Snell; Yang, Song; School of Philanthropy
This study examines social networks and financial giving to charitable or religious causes. Conventional social capital measures of general social trust and size of social network are studied as predictors of charitable giving. To these traditional measures, we add an examination of particular network aspects of giving: ego giving in relation to network alters who give, solicitations to give by network ties, and ego soliciting alters to give. In addition, the study disaggregates alter effects by alter position. Findings indicate that, net of social trust, social network factors significantly predict likelihood of being a giver. In particular, findings are that egos are especially likely to be donors when their primary alter donates. Three configurations of ego–alter giving and solicitations are significant predictors of ego giving, indicating that ego–alter doing matters more than asking. Theoretical contributions for relational and prosocial studies are discussed, as are practical implications for fundraising professionals.
Carboxyl-terminal modulator protein (CTMP) deficiency mitigates denervation-induced skeletal muscle atrophy
(Elsevier, 2023-02) Wang, Junmei; Tierney, Lydia; Wilson, Christopher; Phillips, Victoria; Goldman, Lillian; Mumaw, Christen; Muang, En; Walker, Chandler L.; Biomedical and Applied Sciences, School of Dentistry
Denervated skeletal muscles show decreased Akt activity and phosphorylation, resulting in atrophy. Akt inhibits downstream transcription of atrophy-associated ubiquitin ligases like muscle ring-finger protein 1 (MuRF-1). In addition, reduced Akt signaling contributes to aberrant protein synthesis in muscles. In ALS mice, we recently found that carboxyl-terminator modulator protein (CTMP) expression is increased and correlated with reduced Akt signaling in atrophic skeletal muscle. CTMP has also been implicated in promoting muscle degeneration and catabolism in an in vitro muscle atrophy model. The present study examined whether sciatic nerve injury (SNI) stimulated CTMP expression in denervated skeletal muscle during muscle atrophy. We hypothesized that CTMP deficiency would reduce neurogenic atrophy and reverse Akt signaling downregulation. Compared to the unaffected contralateral muscle, wild-type (WT) gastrocnemius muscle had a significant increase in CTMP (p < 0.05). Furthermore, denervated CTMP knockout (CTMP-KO) gastrocnemius weighed more than WT muscle (p < 0.05). Denervated CTMP-KO gastrocnemius also showed higher Akt and downstream glycogen synthase kinase 3β (GSK3β) phosphorylation compared to WT muscle (p < 0.05) as well as ribosomal proteins S6 and 4E-BP1 phosphorylation (p < 0.001 and p < 0.05, respectively). Moreover, CTMP-KO mice showed significantly lower levels of E3 ubiquitin ligase MuRF-1 and myostatin than WT muscle (p < 0.05). Our findings suggest that CTMP is essential to muscle atrophy after denervation and it may act by reducing Akt signaling, protein synthesis, and increasing myocellular catabolism.

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